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題名 | Acetaminophen急性中毒案例探討=Acute Acetaminophen Poisoning: Two Case Studies |
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作 者 | 曾惠敏; 陳素蜜; | 書刊名 | 藥學雜誌 |
卷期 | 31:4=125 2015.12[民104.12] |
頁次 | 頁60-67 |
分類號 | 418.731 |
關鍵詞 | 解熱鎮痛藥品; 急性中毒; Hepatotoxicity; Drug induced liver injury; Acetaminophen overdose; Acetaminophen poisoning; Paracetamol poisoning; N-acetylcysteine; |
語文 | 中文(Chinese) |
中文摘要 | Acetaminophen 是世界各地廣泛使用的解熱鎮痛藥品,該藥物使用過量的案例也 層出不窮。本文案例一是81歲男性,企圖自殺而一次吞服約18 g acetaminophen 及280 mg tramadol。因呼吸衰竭至醫學中心加護病房治療,3日後轉至本院,生化檢查為: S-GOT 832 IU/L、S-GPT 1384 IU/L,經由醫師診斷為疑似藥物引起的急性及亞急性肝 壞死。案例二為54歲女性,企圖自殺而一次吞服7.5 g acetaminophen,因產生嚴重的 噁心嘔吐而至本院急診治療,醫師診斷為鎮靜劑、安眠藥或抗焦慮藥物的濫用及乙丙 醯衍生物中毒。本文藉由此二案例探討 acetaminophen 中毒的病程、毒性代謝機轉以 及診斷評估與治療。 |
英文摘要 | Acetaminophen is one of the most general antipyretics and analgesics used all over the world, acetaminophen overdose is also common. In the first case, an 81-year-old man took about 18 g acetaminophen and 280 mg tramadol. He was sent to the emergency department subsequently and was admitted to the intensive care unit under the impression of acute respiratory failure, as there was no suspicion of suicidal intentions at that time. And he was referred to our hospital for further care under family's request 3 days later. N-acetylcysteine was not administered until 3 days after acetaminophen ingestion while there was persistent elevation of liver function enzymes. This old man recovered completely and was discharged two weeks later in the end. In the second case, a 54-year-old woman who took 7.5g acetaminophen was sent to our emergency department due to the nausea, vomit and dizziness. This time, N-acetylcysteine was administered immediately and she recovered completely and was discharged 4 days later. This report aims to review cases of acetaminophen poisoning and management. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。