頁籤選單縮合
題名 | Levetiracetam用於輔助治療幼兒癲癇之案例=Levetiracetam Add-on Treatment for Neonatal Seizures |
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作者 | 楊瑛碧; | 書刊名 | 藥學雜誌 |
卷期 | 31:4=125 2015.12[民104.12] |
頁次 | 頁55-59 |
分類號 | 418.21 |
關鍵詞 | 癲癇; 幼兒; Levetiracetam; Seizure; Neonate; |
語文 | 中文(Chinese) |
中文摘要 | 本文報告為18天大的女嬰,因為B型鏈球菌腦膜炎引發癲癇發作的案例。以第 一線藥物 phenytoin 治療失敗後,以 levetiracetam 輔助治療後得到控制。在臺灣小兒 癲癇使用 levetiracetam 於4歲以下的幼童為 off-label use,但在第一線藥物治療失敗 後,目前未有治療指引或是證據指出明確的第二線首選藥品,新一代的抗癲癇藥品中 levetiracetam 具備有良好的藥動特性、副作用相對耐受性佳,同時口服液體劑型有利 劑量調整與嬰幼兒使用,因此做為第一線藥品的輔助治療,為很好的選擇,本次案例 的治療結果也顯示病情控制良好。 |
英文摘要 | This artical reports a 18-day-old baby had seizure attack caused by Group B Streptococcus meningitis. After treat with first-line antiepileptic agent of phenytoin failure, seizure got controled by adding adjunctive levetiracetam therapy. for Levetiracetam is offlabel use in children under 4 years olds in Taiwan. However, there is no treatment guideline or evidence indicating which agents should be a second-line choice when first-line agents has been failure. Levetiracetam is one of the new generation anti-epileptic drugs, which has good pharmacokinetic properties, well-tolerant adverse effect and favorable syrup form allowing easy to use and dosage adjustment for infants. Therefore, levetiracetam may be a good choice as an adjunctive therapy when first-line therapy agents for antiepilepsy treatment has been failure. The neonate in this case showed a good response and seizure control under levetiracetam adjunctive therapy. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。