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頁籤選單縮合
題 名 | 1992~2014年間臺灣流行之百日咳菌的抗原基因型變化=Antigenic Changes in Bordetella pertussis Strains Circulating in Taiwan, 1992~2014 |
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作 者 | 姚淑滿; 陳英彥; 高培修; 溫宜霖; 陳睿翔; 江春雪; | 書刊名 | 疫情報導 |
卷 期 | 32:2 2016.01.19[民105.01.19] |
頁 次 | 頁28-37 |
分類號 | 415.279 |
關鍵詞 | 百日咳; 百日咳菌; 表面抗原; 疫苗; 病原適應; Pertussis; Bordetella pertussis; Surface antigen; Vaccine; Pathogen adoption; |
語 文 | 中文(Chinese) |
中文摘要 | 面對百日咳對國人健康的威脅,政府以提供公費疫苗來預防疾病發生,許多國家疫苗政策皆以非細胞性百日咳疫苗(ACVs)取代全細胞性百日咳疫苗(WCVs),臺灣也自2010年起全面提供ACVs。病原體面對疫苗篩選的壓力,疫苗成份的抗原基因型隨著疫苗的使用驅使轉變,由疫苗株的基因型(ptxA2/prn1或ptxA4/prn1)轉變成非疫苗株的基因型(ptxA1/prn2或ptxA1/prn3),而ptxP也由ptxP1轉變成ptxP3,使病原體可以產生更多的毒力因子,以對抗宿主因疫苗施打而產生的免疫作用。近年來,pertactin不表現的菌株(pertactin-deficient,PRN-)在許多國家出現,導致疾病的流行,臺灣目前大部份的菌株仍然表現pertactin,PRN-菌株只零星出現。抗原的表現直接影響ACVs的保護效果,PRN-菌株的發生率,可以做為疾病流行警訊的參考指標與疫苗選用條件的參考。在疾病罹病率方面,小於1歲的嬰幼兒的罹病率一直居高不下,從國際研究結果得知,目前的ACVs對於疾病的預防有效,但是對於感染傳播的預防無效,因此,完成免疫的學齡前兒童及學童可能受感染但症狀輕微不明顯而成為潛在的病原傳播者,所以,亟需加強民眾對疾病與疫苗的認知,讓年紀太小尚無法得到疫苗免疫保護的嬰幼兒能獲得良好的照護。 |
英文摘要 | Taiwan government began providing free acellular vaccines (ACVs) in 2010, when whole-cell vaccines(WCVs) have been replaced by ACVs in many other countries. Because of selective pressure of vaccines, genotypes of vaccine-component antigens changed from vaccine strains (ptxA2/prn1 or ptxA4/prn1) to non-vaccine strains (ptxA1/prn2), as well as from ptxP1to ptxP3 that produces more virulent factors to counteract immunity induced by vaccines. In recent years, pertactin-deficient (PRN-) strains emerged in several countries, resulting in circulation of pertussis. In Taiwan, majority of B. pertussis strains express pertactin whereas occurrence of PRN- strains was sporadic. Since expression of antigens directly affects efficacy of ACVs, the incidence of PRN- strains could be used as a warning index for disease occurrence and a reference for selecting vaccines. Pertussis in infants who are younger than twelve months old remains high in Taiwan. Some studies suggest that ACVs is effective in disease prevention, but not disease transmission. Therefore, immunized preschool children could be potential B. pertussis carriers and transmit pertussis to younger children. It is important to enforce knowledge on pertussis disease and vaccine in order to provide good care for children who are too young to gain full protection from vaccination. |
本系統中英文摘要資訊取自各篇刊載內容。