查詢結果分析
來源資料
相關文獻
- 常用中藥薏苡仁及其中成藥製劑對胚胎著床之安全性研究
- Lung Cancer in Pregnancy: Report of Two Cases
- Lactation Promotes the Normalization of Plasma Lipids and Lipoproteins after Delivery in Taiwanese Women
- Spontaneous Uterine Rupture during Pregnancy
- 懷孕週數與低出生體重及極低出生體重嬰兒盛行率之研究
- 中藥材微量有機氯農藥之超臨界流體檢驗方法之研究
- 中藥(材)中微量元素之檢驗方法及規格研訂2.--植物性中藥(材)中微量元素(銅、汞、鎘、鉛、砷、鈷、錳)檢驗方法及規格研訂之研究
- 中藥(材)中微量元素(銅、汞、鎘、鉛、砷、鈷、錳)之檢驗方法及規格研訂的整合型研究計畫。子計畫4:動物中藥(材)中微量元素(銅、汞、鎘、鉛、砷、鈷、錳)檢驗方法及規格研訂之研究
- 中藥(材)中微量元素之檢驗方法及規格研訂4.--礦物中藥(材)中微量元素(銅、汞、鎘、鉛、砷、鈷、錳)檢驗方法及規格研訂之研究
- 未去勢雄性肉豬含男性脂酮和糞臭素含量影響豬肉腥臭味以及懷孕母豬飼料含葉酸對於繁殖表現之研究報導
頁籤選單縮合
題 名 | 常用中藥薏苡仁及其中成藥製劑對胚胎著床之安全性研究=Elucidate the Effect of Adlay (Coix Lachryma-jobi L. var. ma-yuen Stapf) Seed and Its Traditional Chinese Medicine on Embryo Implantation |
---|---|
作 者 | 楊友仕; | 書刊名 | 中醫藥年報 |
卷 期 | 3 2014.12[民103.12] |
頁 次 | 頁(40)1-(40)42 |
分類號 | 414.5 |
關鍵詞 | 中藥材; 薏苡仁; 中成藥; 懷孕; 胚胎著床; Adlay seed; Chinese medicine; Embryo implantation; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究計畫的主要目標為運用生殖醫學的科學研究方法探討薏苡仁對胚胎著床之效應與可能的作用機制,以驗證中藥材薏苡仁在生殖醫學之毒理與藥效,來達到降低薏苡仁相關產品對生殖造成的副作用,提高薏苡仁在其他療效之方便性與安全性等。 本研究結果顯示薏苡仁煮湯後的湯劑、薏苡仁煮湯後的顆粒、薏苡仁漿及中成藥薏苡仁錠,確實會在特定劑量連續餵食的情況下對小鼠胚胎植入的懷孕模式造成影響。薏苡仁樣品會造成子宮內膜組織之間質細胞的組織病理型態,對子宮內膜組織中與懷孕過程有關的重要細胞激素生長因子的基因表現有抑制的趨勢,對子宮內膜組織之上皮細胞與間質細胞之固著相關分子也會產生影響。進一步利用薏苡仁指標成分的研究也發現,確實具有會影響體外胚胎著床之指標成分,這些指標成分會對子宮內膜細胞株 RL-95-2之重要細胞固著相關分子表現會造成影響,我們也發現將這些指標成分,以特定劑量連續餵食也會對小鼠胚胎植入的懷孕模式造成影響,其機制與抑制子宮內膜組織中已知重要細胞激素與生長因子的基因表現有關。本研究計畫以系統生物學的概念由活體到分子機制探討中藥材薏苡仁與其指標成分在生殖醫學之效應,研究成果將能提供薏苡仁在藥用或食用上對於生殖醫學安全性的重要依據。此模式也將有助於建立中藥材在生殖醫學之安全性規範。 |
英文摘要 | Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed is a traditional Chinese medicine and as a nutritious food. Pregnant women are suggested not to eat adlay seed in the opinion of Chinese medicine. However, the scientific mechanisms of the adlay seed on embryo implantation are unclear. The major aim of this project is to elucidate the effect of adlay seed and its related Chinese herb reagents on embryo implantation and clarify the possible mechanisms of this effect. The results would help to establish the safety rules for the usage of adlay seed and its related Chinese herb reagents. In this study we evaluate the effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed and its traditional Chinese medicine on embryo implantation with the technologies for in vitro and in vivo embryo implantation experiments. The results demonstrate that: 1. Commercialized adlay seed could inhibit the embryo implantation by administration adlay seed and its related products with animal model. 2. The mechanisms of adlay seed and its related products on abortion are independent of pregnancy related endocrine molecular, such as E2、P4、oxytocin in serum level. 3. The indicator components and therapeutic components of adlay seed do play critical role on embryo implantation with in vitro model. 4. Certain indicator components and therapeutic components of adlay seed do inhibit the embryo implantation in the in vivo model. The project contains the concept of system biology. The results can help to realize the safety of adlay seed and its related Chinese herb reagents on pregnant women and may help to establish the safety rules for the usage of adlay seed and its related Chinese herb reagents. |
本系統中英文摘要資訊取自各篇刊載內容。