頁籤選單縮合
題 名 | 中藥水煎劑與濃縮方劑比較研究(3-1)=The Comparative Researches between Traditional Herbal Decoction and Commercial Extract (3-1) |
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作 者 | 詹道明; | 書刊名 | 中醫藥年報 |
卷 期 | 光碟版1:10 2012.10[民101.10] |
頁 次 | 頁267-327 |
專 輯 | 中醫藥產業應用開發 |
分類號 | 413.97 |
關鍵詞 | 疏經活血湯; 川芎茶調散; 銀翹散; 葛根湯; 麻杏甘石湯; 辛夷清肺湯; 芍藥甘草湯; 生體相等性; 水煎劑; 濃縮製劑; Shu Jing Huo Xue Tang; Chuan Xiong Cha Tiao San; Yin Qiao San; Ge Gen Tang; Ma Xing Gan Shi Tang; Shin Yi Ching Fey Tang; Shaur Yaw; Gan Taso Tang; Bioequivalence; Traditional decoction; Commercial; Extract; |
語 文 | 中文(Chinese) |
中文摘要 | 目前臺灣中醫臨床上使用之中藥劑型主要為傳統水煎劑及濃縮製劑,少有評估濃縮製劑與傳統水煎劑在療效上相等性之研究;本計畫將以健保局常用方劑為研究對象,包含疏經活血湯、川芎茶調散、銀翹散、葛根湯、麻杏甘石湯、辛夷清肺湯、芍藥甘草湯。同時開發各種指標成分 HPLC快速分析方法,HPLC的靈敏度試驗、精確性試驗、相對回收率試驗、分析安定性試驗等確效試驗之驗證。動物實驗中,雄性紐西蘭大白兔口服兩種劑型之相對生可用率研究部分,我們以水煎劑為基準,投予動物相當於化學相當量之濃縮散劑,實驗採交叉設計。運用藥物動力學軟體,評估濃縮製劑與水煎劑之間的生體相等性,根據本實驗結果發現,指標成分的選擇對於評估二者間的生體相等性是很重要的。 |
英文摘要 | At present, both traditional decoction and commercial extract are two major dosage forms of clinic traditional Chinese medicine in Taiwan. The investigations of bioequivalence between traditional decoction preparation and commercial extract were not extensively studied yet. The purpose of this research is to study bioequivalence of seven commercial extracts and their counter traditional decoction, including Shu Jing Huo Xue Tang, Chuan Xiong Cha Tiao San, Yin Qiao San, Ge Gen Tang, Ma Xing Gan Shi Tang, Shin Yi Ching Fey Tang and Shaur Yaw Gan Taso Tang, respectively. The rapid and sensitive quantitative methods for the determination of the index components of these formulations were developed and validated by using HPLC. Male New Zealand rabbits were administered with traditional decoction and commercial extract in crossover design. The pharmacokinetic software, Winnolin 4.0, is utilized for evaluating bioequivalence between traditional decoction and commercial extract. In general the experimental results indicate that the choosen index components played an important role on the outcomes of the evaluation. |
本系統中英文摘要資訊取自各篇刊載內容。