頁籤選單縮合
| 題 名 | 甲醇與乙二醇之解毒劑--Fomepizole=Fomepizole: An Antidote for Methanol or Ethylene Glycol Poisoning |
|---|---|
| 作 者 | 林佳霖; 莊美華; 劉麗玲; 黃淑萍; 祁若鳳; | 書刊名 | 藥學雜誌 |
| 卷 期 | 31:3=124 2015.09[民104.09] |
| 頁 次 | 頁38-42 |
| 分類號 | 418.82 |
| 關鍵詞 | 酒精去氫酶; 甲醇; 乙二醇; Fomepizole; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | Fomepizole 為酒精去氫酶 (alcohol dehydrogenase,ADH) 的競爭型抑制劑,適應 症為甲醇 (methanol) 或乙二醇 (ethylene glycol) 中毒之解毒劑,fomepizole 建議劑量為 給予15 mg/kg 的起始劑量後,之後每12小時給予10 mg/kg 劑量,以此劑量投藥4次, 再每12小時給予15 mg/kg 劑量持續治療,直到血中乙二醇及甲醇濃度低於20 mg/dL, 血液 pH 值正常且無中毒症狀為止。Fomepizole 可藉由抑制 ADH 酵素活性的作用, 抑制甲醇及乙二醇的起始代謝,避免甲醇與乙二醇代謝過程產生的代謝毒性產物所引 發的神經毒性與腎臟毒性、心臟毒性。 |
| 英文摘要 | Fomepizole is a competitive inhibitor of alcohol dehydrogenase (ADH). Fomepizole is indicated as an antidote for methanol or ethylene glycol poisoning. For the case of suspected or confirmed methanol or ethylene glycol intoxication, fomepizole should be administered intravenously as a loading dose of 15 mg/kg, followed by 10 mg/kg every 12 hr for 4 doses, then 15 mg/kg every 12 hr until plasma or blood concentrations of ethylene glycol or methanol are below 20 mg/dL. By blocking the initial metabolism of methanol and ethylene glycol through ADH inhibition, fomepizole ceases the initiation of the metabolic toxicity cascade from neurological effects to renal and cardiovascular toxicity. |
本系統中英文摘要資訊取自各篇刊載內容。