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- 探討加入Cilostazol的三重抗血小板療法
頁籤選單縮合
題名 | 探討加入Cilostazol的三重抗血小板療法=The Role of Cilostazol in Addition to Dual Antiplatelet Therapy? |
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作者姓名(中文) | 康建文; | 書刊名 | 藥學雜誌 |
卷期 | 31:2=123 2015.06[民104.06] |
頁次 | 頁18-24 |
分類號 | 418.23 |
關鍵詞 | 抗血小板活性; Cilostazol; Dual antiplatelet therapy; Triple antiplatelet therapy; Stent thrombosis; |
語文 | 中文(Chinese) |
中文摘要 | 支架再狹窄與支架栓塞是冠狀動脈支架手術後的主要併發症。依準則建議,無論 使用何種支架,術後併用 aspirin 及 P2Y12受體阻斷劑 (以 clopidogrel 為主) 之雙重抗 血小板藥物 (dual antiplatelet therapy,DAPT) 是標準療法。但受限於 clopidogrel 的之 藥效作用延遲,以及 CYP2C19的基因多型性 (genetic polymorphism) 導致個體間不同 程度的抗血小板反應而影響療效。目前有研究加上 cilostazol 的三重抗血小板凝集療 法 (triple-antiplatelet therapy,TAPT),相對於 aspirin 加上 clopidogrel,可有效降低支 架手術後栓塞的風險,但效果仍未確立。因此本文探討 DAPT 加上 cilostazol 的三重 抗血小板凝集療法的安全性與有效性,以提供臨床應用的可能。 |
英文摘要 | Stent restenosis and stent thrombosis is a major complication after coronary stent implantation. According to the guideline, when using any type of stent combined aspirin with ADP receptor inhibitors (especially in clopidogrel) called dual antiplatelet therapy (DAPT) is the gold standard. But some limitations of clopidogrel decrease the efficacy of delayed the onset and the genetic polymorphism of cytochrome enzyme-CYP2C19 resulting the difference of antiplatelet activation between individuals. At present, cilostazol in addition to standard regimen (aspirin and clopidogrel) called triple antiplatelet therapy (TAPT) might have a beneficial effect on the prevention of thrombotic complications following coronary stenting, but remains unclear. Therefore, this article will discuss the efficacy and safety of TAPT after stent implantation for clinical applications. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。