頁籤選單縮合
題名 | 2010~2012年臺灣地區HIV-1新通報個案抗藥性監測=Surveillance of Drug-resistance of Newly Diagnosed HIV-1 Infected Patients in Taiwan, 2010~2012 |
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作者姓名(中文) | 陳必智; 高振峰; 林咏臻; 楊志元; | 書刊名 | 疫情報導 |
卷期 | 30:24 2014.12.23[民103.12.23] |
頁次 | 頁518-526 |
分類號 | 412.4 |
關鍵詞 | 人類免疫缺乏病毒; 愛滋病; 抗藥性; Human immunodeficiency virus type-1; HIV-1; Acquired immune deficiency syndrome; AIDS; Drug-resistance; |
語文 | 中文(Chinese) |
中文摘要 | 人類免疫缺乏病毒(Human immunodeficiency virus, HIV)為反轉錄病毒科(retroviridae)中的緩慢病毒(lentivirus)之一,感染發病後會導致後天免疫缺乏症候群(acquired immunodeficiency syndrome, AIDS),也就是一般俗稱的愛滋病。目前,絕大多數的抗病毒藥物,是藉由干擾與HIV-1活性或複製相關的基因產物,達到抑制病毒複製的效果。但在病患接受治療過程中,可能因為病毒變異及患者服藥順從性不佳等因素,在患者體內衍生出抗藥性病毒株,導致患者體內的病毒複製無法被抑制,進而影響到治療的效果。這些抗藥性病毒株的產生,亦有可能造成原生抗藥性病毒株的傳播。疾病管制署(簡稱疾管署)研究檢驗中心近年來持續對臺灣地區HIV-1抗藥性情形進行監控。在2010-2012年間,依危險因子與居住地區等參數來採樣當年度新通報之HIV-1病例進行檢測,分析HIV-1具有抗藥性之盛行率分別為9.8%、6.6%及7.4%。本研究結果將有助於了解HIV-1抗藥性現況,並提供防疫政策之參考依據。 |
英文摘要 | Human immunodeficiency virus type-1 (HIV-1) is the pathogen causes the acquired immune deficiency syndrome (AIDS). The HIV-1 virus of drug-resistance might produce widespread transmission of primary HIV-1 virus of drug-resistance, and could discount and influence the efficiency of therapy. By monitoring the naive patients and build database, these are the important references for not only examination of drugs used in Taiwan but also a recommendation for clinicians to consider drugs. We studied the prevalence of transmitted HIV-1 drug resistance in Taiwan between 2010 and 2012, and revealed that the mutation rate of ARV drug-resistance from newly diagnosed patients with HIV-1 was 9.8%, 6.6% and 7.4%, respectively. The results of this study will improve understand of serious situation of HIV-1 drug-resistance and realize its impact. In conclusion, we will obtain more complete blueprint of epidemiology of HIV-1 drug-resistance and provide a reference for policy making by government institutions and medical units. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。