頁籤選單縮合
題 名 | 脂肪分佈異位與人類免疫缺乏病毒感染=Lipodystrophy and Human Immunodeficiency Virus Infection |
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作 者 | 蘭淑貞; | 書刊名 | 中華民國營養學會雜誌 |
卷 期 | 27:3 2002.09[民91.09] |
頁 次 | 頁118-128 |
分類號 | 415.1156 |
關鍵詞 | 脂肪分佈異位; 人類免疫缺乏病毒; 愛滋病毒; 人類免疫缺乏症候群; 愛滋病; 抗病毒藥物; Lipodystrophy; Human immunodeficiency virus; HIV; Acquired human immunodeficiency syndrome; AIDS; Antiretroviral drugs; |
語 文 | 中文(Chinese) |
中文摘要 | 人類免疫缺乏病毒(human immunodeficiency virus, HIV)〔簡稱愛滋病毒〕暨人類免疫缺乏症候群(acquired human immunodeficiency syndrome, AIDS)〔簡稱愛滋病〕(HIV/AIDS)為世界性健康問題,死亡率高居第一位。抗HIV藥物的開發與使用快速降低HIV/AIDS罹病率與死亡率,卻產生「脂肪分佈異位」(lipodystrophy)副作用,此為近兩三年歐美澳地區最熱門議題。本文就脂肪分佈異位做一綜論性報告包括:世界和台灣HIV/AIDS流行現況;脂肪分佈異位之定義、分類與特徵;脂肪分佈異位在HIV感染者之發生率;與HIV感染者脂肪分佈異位有關之因素包括HIV、抗HIV藥物包括蛋白?抑制劑、核?酸反轉錄?抑制劑、非核?酸反轉錄?抑制劑與其他藥物、用藥時間與對藥物耐受性、性別、身體質量指數(BMI)與身體組成、年齡、免疫功能、賀爾蒙、飲食/營養狀況、運動;脂肪分佈異位對HIV感染者的影響;治療脂肪分佈異位方法包括停藥或轉換療法、飲食/營養療法、運動療法、降血脂、血糖藥物療法,荷爾蒙療法與整形手術-抽脂術或脂肪移植。對脂質代謝異常、血糖上升、胰島素抗性或糖尿病患者,除了採用飲食/營養療法與運動療法外,可同時採用降血脂、血糖藥物療法。 |
英文摘要 | Human immunodeficiency virus (HIY)/acquired human immunodeficiency syndrome (AIDS) is a major public health problem worldwide, since it is the number one leading cause of death in certain underdeveloped countries. Although many anti-HIV drugs, which dramatically decrease morbidity and mortality associated with HIV / AIDS, are available in developed countries, long-term use of these drugs has been associated with the undesirable side effect of lipodystrophy, a very hot issue over the past 2~3 years in those countries. This review includes the following: 1) a review of the epidemic of HIV / AIDS in Taiwan as well as worldwide; 2) a definition, classification, and the characteristics of lipodystrophy; 3) the prevalence of lipodystrophy in people living with HIV (PLWH); 4) factors associated with lipodystrophy in PLWH such as HIV, antiretroviral drugs including protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTIs), non nucleoside reverse transcriptase inhibitors (NNRTIs), and other drugs; the duration of drug therapy and drug tolerability, gender, body mass index (8MI) and body composition, age, immunity, hormones, diet/nutrition, and exercise: 5) the influence of lipodystrophy on PLWH; and 6) treatments for lipodystrophy including switching therapies or stopping drugs, diet/nutrition therapies, exercise, drug therapies to lower blood lipid or glucose, hormonal therapy , and plastic surgery such as liposuction, lipectomy or fat grafts. For those with dyslipidemia, hyperglycemia, insulin resistance, or diabetes mellitus, in addition to the therapies of diet/nutrition and exercise, blood lipid- or glucose-lowering drugs can be used. |
本系統中英文摘要資訊取自各篇刊載內容。