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題名 | 帶狀疱疹與帶狀疱疹後神經痛=Herpes Zoster and Postherpetic Neuralgia |
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作者姓名(中文) | 吳佩霖; 石真宜; 石成展; | 書刊名 | 藥學雜誌 |
卷期 | 29:4=117 2013.12[民102.12] |
頁次 | 頁90-95 |
分類號 | 415.723 |
關鍵詞 | 帶狀疱疹; 帶狀疱疹後神經痛; 藥物治療; Herpes zoster; Postherpetic neuralgia; Pharmacotherapy; |
語文 | 中文(Chinese) |
中文摘要 | 帶狀疱疹 (herpes zoster)由水痘帶狀疱疹病毒所引起,人體感染水痘痊癒後,此病毒便潛伏在神經節中伺機而動,一旦年紀老化或免疫力下降,病毒可能再活化而使帶狀疱疹發作,症狀包含紅疹、水疱,甚至引起疼痛,一但發病,必須在 72小時內投與抗病毒藥品,緩解症狀並預防併發症。若疼痛在紅疹或水泡消失後仍持續 3個月以上,則可診斷為帶狀疱疹後神經痛 (postherpetic neuralgia),緩解神經痛的第一線藥為抗癲癇藥品中的 gabapentin與 pregabalin、三環抗憂鬱藥、 lidocaine貼片;其他可選擇的治療尚有類鴉片止痛劑 (opioids)、外用辣椒素 (capsaicin)。臨床處置上,若單用一種藥品療效不佳,可能會使用兩種或以上不同機轉的藥品合併治療,以達最佳療效。 |
英文摘要 | Herpes zoster (HZ) is caused by varicella zoster virus (VZV). After primary infection with varicella, the virus persists in the ganglia. The reactivation occurs when immunity to VZV declines because of aging or immunosupperssion. The symptoms of HZ are skin rash, red macules, and pain. Anti-viral agents should be initiated within 72 hours of HZ onset to relieve the symptoms and prevent complications. Postherpetic neuralgia (PHN), defined as pain persisting more than 3 months after the rash has healed. First-line therapies for PHN include anti-convulsants (gabapentin, pregabalin), tricyclic antidepressants, and lidocaine patch. Other therapies include opioids and topical capsaicin. In the clinical management of PHN, combination therapy with two or more agents that display different mechanisms of action may provide better efficacy in patients who do not respond to either treatment alone. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。