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題名 | 白藜蘆醇抗糖尿病作用的分子機轉=Molecular Mechanism of Resveratrol on Antidiabetic Properties |
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作者 | 施純青; Shih, Chun-ching; |
期刊 | 藥學雜誌 |
出版日期 | 20131200 |
卷期 | 29:4=117 2013.12[民102.12] |
頁次 | 頁28-31 |
分類號 | 414.51 |
語文 | chi |
關鍵詞 | 白藜蘆醇; 組蛋白去乙醯基酶; AMP激活的蛋白激酶; Resveratrol; SIRT1; AMPK; |
中文摘要 | 白藜蘆醇為一廣泛存在於植物多酚類化合物,是一種植物抗毒素,存在於紅酒和葡萄。近年來,許多研究顯示白藜蘆醇對人類健康的益處,如降低血糖、改善胰島素阻抗、調節異常的脂質代謝、抗老化、抗氧化、抗發炎、抗腫瘤防癌等作用。這些作用主要是通過細胞內多個訊息傳遞路徑的調節,包括 silent information regulator-mammalian ortholog (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator (PGC-1α)路徑、核因子 κB抑制物激酶 -β (inhibitor of KappaB Kinase-β, IKK-β)/核因子 κB抑制物 (IκB)/核因子 κB (nuclear factor-κB, NF-κB)路徑、磷酸腺苷激酶 (AMPactivated protein kinase; AMPK)等路徑和分子標靶。 |
英文摘要 | Resveratrol is widely distributed group of plant polyphenols (such as red wine and grapes) and characterized by a phytoalexin. Currently, studies demonstrated that resveratrol could exert many beneficial biological activities including causing glucose lowering effect, improving insulin resistance, regulating abnormal lipid metabolism, anti-ageing, anti-oxidation, chemotherapy and chemoprevention. These effects are due to regulate many cellular signaling pathways, including silent information regulator-mammalian ortholog (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator (PGC-1α), inhibitor of KappaB Kinase-β (IKK-β)/inhibitor of nuclear factor-κB (IκB)/Nuclear factor-κB (NF-κB), AMP-activated protein kinase (AMPK) and targeted molecules. |
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