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題 名 | Subclinical Renal Tubular Dysfunction in Patients with Mild Essential Hypertension: Implications from a Prospective, Small Cohort Study on Urinary Enzymes Excretion=輕度本態性高血壓病人的早期胃小管功能損傷:一個有關尿液酵素檢測的前瞻性、小型世代研究 |
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作 者 | 何泰儀; 彭渝森; 白美芬; 楊紹佑; 洪冠予; | 書刊名 | 臺灣腎臟醫學會雜誌 |
卷 期 | 19:3 民94.09 |
頁 次 | 頁109-112+148 |
分類號 | 415.382 |
關鍵詞 | 本態性高血壓; Essential hypertension; N-acetyl-β-D-glucosaminidase; β₂-microglobulin; γ-glutamyl transpeptidase; NAG; B₂M; γ-GT; |
語 文 | 英文(English) |
中文摘要 | 本態性高血壓對於腎臟的腎小管功能有何影響,目前仍有許多不清楚之處。我們以前瞻性研究的方式,測量本態性高血壓病患其尿中N-acety1-β-D-glucosaminidase(NAG),β2-microglobulin(B2M)以及γ-glutamyl transpeptidase(γ-GT)三種尿液酵素的活性,以探討這類病人的腎小管功能受疾病影響的狀況。本研究的對象為38位新近診斷為輕度本態性高血壓、且血中肌酐酸濃度≤1.2 mg/dL的病人;並有36位相對應的對照組。輕度本態性高血壓的診斷標準即為JNC-VI報告中的高血壓第一期:收縮壓140-159或舒張壓90-99毫米汞柱。每位研究對象均收集24小時尿液樣本,測定血清及尿液中肌酐酸濃度、尿中白蛋白排除量(urine albumin excretion)、以及尿中 NAG、B2M、γ-GT的活性(以對肌酐酸濃度的比值表示)。本研究的結果顯示,在輕度本態性高血壓的病患,其尿中B2M有顯著升高的現象。而相較於對照組,尿中γ-GT活性有降低的趨勢(p=0.08),尿中NAG活性則有升高的趨勢(p=0.07)。所有本態性高血壓的病患追蹤三個月後,其尿中白蛋白排除量及肌酐酸清除率均未改變。然而,我們發現在高血壓的病患,三個月後的尿中B2M活性較先前之基礎值有顯著的上升(從5.71±3.4上升至8.47±2.1μg/mmol creatinine; p<0.01);而尿中γ-GT活性則有顯著的下降(從29.6±7.4下降至26.4±8.2U/mmol creatinine; p<0.01)。因此我們認為在輕度本態性高血壓的病患,即使其尿中白蛋白排除量不顯著,也可能有不正常的尿液酵素存在;測量這些尿液酵素可能有助於早期發現輕度本態性高血壓病患的腎小管功能損傷。 |
英文摘要 | Background: The effect of essential hypertension (EH) on renal tubular function is still unclear. To evaluate renal tubular function in EH patients, we conducted a prospective study on the activity of the urinary N-acetyl-ß-D-glucosaminidase (NAG), ß2-microglobulin (B2M) and γ-glutamyl transpeptidase (γ-GT) in these patients. Methods: Thirty-eight patients newly identified with untreated mild EH and no signs of renal damage (plasma creatinine levels ≤1.2 mg/dL) were studied in contrast with 36 control subjects. The diagnostic criteria of mild EH followed the report of the JNC-VI (hypertension stage 1: systolic BP 140-159 or diastolic BP 90-99 mmHg). Serum and urinary creatinine, urine albumin excretion (UAE) and NAG were determined photometrically. Urine γ-GT was assayed spectrophotometrically, and urinary B2M was obtained by radioimmunoassay. Results. A significantly higher value of urinary B2M excretion was found in patients with mild EH. Urinary γ-GT activity tended to be lower (p=0.08) and urinary NAG activity tended to be higher (p=0.07) in the EH group than in the control group. All EH subjects were observed for three months, and no significant difference in the levels of UAE and creatinine clearance were found. However, EH patients exhibited a significant elevation in B2M activity from 5.71±3.4 to 8.47±2.1 μg/mmol creatinine (p<0.01), and a significant decline of γ-GT activity from 29.6±7.4 to 26.4 ±8.2 U/mmol creatinine (p<0.01). Conclusions: We demonstrated that abnormal urinary enzyme variables may exist in mild EH patients, regardless of the absence of significant UAE. Measurement of the urinary excretion of enzyme variables is worthwhile and may detect early renal tubular injury in mild EH patients. |
本系統中英文摘要資訊取自各篇刊載內容。