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題名 | 益生菌降低幽門螺旋桿菌之療效=Inhibitory Activity of Probiotics on Helicobacter Pylori |
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作者 | 李建瑩; 施宏哲; | 書刊名 | 藥學雜誌 |
卷期 | 30:1=118 2014.03[民103.03] |
頁次 | 頁106-110 |
分類號 | 415.5 |
關鍵詞 | 幽門螺旋桿菌; 三合一療法; 益生菌; Helicobacter pylori; Triple therapy; Probiotics; |
語文 | 中文(Chinese) |
中文摘要 | 目前治療幽門螺旋桿菌的方法,主要是三合一療法,常是併用一種質子幫浦抑制劑 (proton pump inhibitor) 加上兩種抗生素,它的副作用比率高,病人順從性低,而且容易因為細菌抗藥性及細菌感染的量,而導致治療失敗,所以一些溫和、安全、簡單療法開始引人注意,例如益生菌降低幽門螺旋桿菌為一值得研究的題材。 益生菌抑制 Hp 生長的機轉包括非免疫學與免疫學二部分。(1) 在非免疫學方面,益生菌可分泌抗菌物質抑制 Hp 生長,也會抑制 Hp 附著於胃腸道黏膜。(2) 在免疫學方面,使用益生菌抑制 Hp 的作用與 Th1免疫反應有關,益生菌可增加 IL-10,IL-10增加後可減少 Hp 的 IgG 抗體,降低 Hp 特殊抗體的產生。 合併使用抑制 Hp 的抗生素與益生菌可增加根除 Hp 的作用,在臨床上可運用此種治療方式在三合一療法失敗的病人。 |
英文摘要 | The most commonly used regimen for Helicobacter Pylori (H. pylori) eradication is triple therapy, consisting of a proton pump inhibitor and two antibiotics. Triple therapy has a higher rate of side effects and lower compliance and tend to fail as a result of bacterial resistance and the severity of the bacterial infection. Therefore, safe and simple therapies started to draw attention. Among them, the use of probiotics to reduce H. pylori merits further investigation specially as data on the safety of probiotics suggesting that probiotic therapy is generally considered safe. Several mechanisms by which probiotic bacteria can inhibit H. pylori, including nonimmunologic and immunologic mechanisms. In nonimmunologic mechanism, probiotics may inhibit H. pylori growth by secreting antibacterial substances and inhibiting the attachment of H. pylori to gastrointestinal mucosa. In immunologic mechanisms, when using probiotics for the treatment of clinical conditions associated with a Th1 immune response, it should be noted that probiotics are capable of up-regulating IL-10. It is possible that increased levels of IL-10 may have contributed to the observed the decrease in H. pylori-specific IgG antibodies. This cytokine has previously been shown to down-regulate H. pylori-specific antibody production. Supplementation of anti-H. pylori antibiotic regimens with certain probiotics may also be effective in increasing eradication rates and may be considered helpful for patients with eradication failure. This therapy may be considered helpful for patients with eradication failure. |
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