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頁籤選單縮合
題名 | Rasburicase-induced Methemoglobinemia and Hemolysis in a Patient with Malignant Lymphoma=在一個惡性淋巴瘤的病人使用Rasburicase造成變性血紅素血症與溶血 |
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作者 | 古凡宸; 林瑛珠; 張景明; 楊陽生; 黃文豊; | 書刊名 | 臺灣癌症醫學雜誌 |
卷期 | 29:1 2013.03[民102.03] |
頁次 | 頁22-27 |
分類號 | 418.22 |
關鍵詞 | 高尿酸血症; 變性血紅素; Rasburicase; Hyperuricemia; Methemoglobin; |
語文 | 英文(English) |
中文摘要 | 目的:報告一個因為 rasburicase 造成變性血紅素血症(methemoglobinemia)與溶血的病患。 病例報告:一個未帶有 G6PD 酵素缺乏的 87 歲男性在診斷瀰漫性大 B 細胞淋巴瘤之後, 產生了急性腎衰竭與高尿酸血症,在給予 rasburicase 之後產生了一個急速的變性血紅素 血症與溶血。病患接受了輸血治療後復元,腎功能與高尿酸血症在此病程後也恢復正常。 結論:Rasburicase 造成的變性血紅素血症與溶血可以發生在沒有 G6PD 缺乏的病患,且 可以單純輸血治療處理。 |
英文摘要 | Objective: To describe a case of rasburicase-induced methemoglobinemia and hemolysis in a patient with malignant lymphoma. Case Report: An 87-year-old man without G6PD deficiency presented with acute renal failure and hyperuricemia after diagnosis of diffuse large B-cell lymphoma. After two doses of rasburicase infusion, an abrupt onset of hemolysis and methemoglobinemia developed. The patient received a blood transfusion and thereafter recovered, and his renal function and hyperuricemia also restabilized following this episode. Conclusions: Rasburicase-induced methemoglobinemia and hemolysis occurs in patients without G6PD deficiency and can be treated by blood transfusion alone. |
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