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題 名 | 疑似Fludiazepam引起EPS症候群=Fludiazepam Induced Extrapyramidal Syndrome |
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作 者 | 廖文聰; 蕭如君; 蔡敏鈴; | 書刊名 | 藥學雜誌 |
卷 期 | 28:4=113 2012.12[民101.12] |
頁 次 | 頁101-105 |
分類號 | 418.21 |
關鍵詞 | 抗焦慮劑; 肌張力不全; 錐體外徑症候群; Erispan; EPS; Dystonia; Benzodiazepine; Biperiden; |
語 文 | 中文(Chinese) |
中文摘要 | Fludiazepam (Erispan )是屬於 benzodiazepine類的抗焦慮劑,臨床上常用來作為患者焦慮狀態、失眠、肌肉痙攣狀況之解除,常見的副作用為嗜睡、頭暈目眩、倦怠感⋯等。本案例描述一位 42歲女性患者服用了過量的 fludiazepam隔日即出現錐體外徑症候群 (extrapyramidal syndromes; EPS)症狀中的肌張力不全 (dystonia),在給予 biperiden 5 mg靜脈輸注約 3小時後,患者症狀才得以解除。 Benzodiazepine類藥品可做為 EPS症狀中肌肉痙攣狀況的治療,至於服用此類藥品後反而產生 EPS的狀況實屬罕見,因此藉由文獻的蒐尋相關的證據來探討其中的相關性以便能夠更安全的使用 fludiazepam類藥品。 |
英文摘要 | Fludiazepam (Erispan ) is an anti-anxiety agent of benzodiazepines and plays a role in treatment of anxiety, insomnia and muscle spasm symptoms. It has been reported some adverse effects about drowsiness, dizziness, fatigue, etc. However, the side effects of extrapyramidal syndrome (EPS) induced by fludiazepam were rarely reported. This case described a 42-years-old female patient, who suffered from dystonia of EPS due to taking overdose of fludiazepam. The physician prescribed biperiden 5 mg via intravenous injection and then the syndrome relieved after three hours. The incidence associated with EPS was rarely described in the patients thking benzodiazepines. Therefore, through literature review, we tried to disscuss the safety of fludizepam. |
本系統中英文摘要資訊取自各篇刊載內容。