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題名 | 廣泛性焦慮症患者Buspirone, Lorazepam與Diazepam治療雙盲試驗=Double Blind Trials of Buspirone, Lorazepam and Diazepam in the Treatment of Generalized Anxiety Disorder |
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作者 | 黃介良; 楊延光; 陳怡廷; 陳純誠; | 書刊名 | 臺灣精神醫學 |
卷期 | 13:2 1999.06[民88.06] |
頁次 | 頁62-72 |
分類號 | 418.214 |
關鍵詞 | 泛焦慮症; 治療效果; 副作用; 抗焦慮劑; Generalized anxiety disorder; Therapeutic effect; Side effect; Anxiolytic agents; |
語文 | 中文(Chinese) |
中文摘要 | 目的:本研究之目的為比較buspirone (B) 和 lorazepam (L) 及diazepam (D) 在廣泛性焦慮症之臨床療效及副作用。方法:採雙盲研究設計方式,從門診選取廣泛性焦慮 症病患,經病患同意後,隨機分為三組,包括 B 組:19 位,L 組:20 位,D 組:20 位, 經一週安慰劑廓清後,以固定劑量( B 藥:每天 20 毫克,L 藥:每天 2 毫克,D 藥:每 天 10 毫克)治療四週。結果:顯示三組之療效相當,治療後在焦慮及憂鬱量表得分治療效 果均呈顯著改善,但 L 組及 D 組比 B 組較快速出現顯著;B 藥及 L 藥在治療結束後之注 意力評估均呈顯著改善,D 藥則未達顯著差異;在治療過程中,B 藥副作用以噁心、頭輕及 發抖為主,L 藥副作用以發抖、頭輕及嗜睡為主,D 藥副作用則以嗜睡、頭暈及口乾為主。 結論:B 藥、L 藥及 D 藥廣泛性焦慮症短期療效約略相當, 然各藥均有不同的輕微副作用 。 |
英文摘要 | Objectives: Benzodiazepam is commonly used in the treatment of generalized anxiety disorder. Nonbenzodiazepam anxiolytics such as buspirone have also been used with few side effects. This double-blinded study compared the therapeutic effectiveness and side effects of buspirone (20 mg/day), lorazepam (2 mg/day) and diazepam (10 mg/day). Methods: A total of 59 patients with generalized anxiety disorder who were consecutively admitted to an outpatient clinic service were enrolled in the study. The patients were randomized into three groups to receive either buspirone (19 cases), lorazepam (20 cases), and diazepam (20 cases). Results: The results showed that these three regimens had similar drug compliance and therapeutic effect. The lorazepam and diazepam groups achieved a faster effect compared to the buspirone group. The buspirone and lorazepam groups showed significant improvement on attention test scores while the diazepam group showed no improvement. Patients in the buspirone group showed side-effects of nausea, lightness and tremor; those in the lorazepam group showed light-headedness, tremor and drowsiness; while those in the diazepam group showed drowsiness, dizziness and dry mouth. Conclusion: The anxiety and depression scores improved significantly after all treatment in three groups of patients. It seems that the comparing the side effects of three drugs simultaneously is different. (Full Text in Chinese) |
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