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題名 | Tubulopapillary Carcinoma--A Frequent Over-Diagnosed Entity in Canine Mammary Gland Tumors=管狀乳突癌--一種經常被過度診斷的犬乳腺腫瘤 |
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作 者 | 朱旆億; 葉仲敏; 葉坤土; 劉振軒; | 書刊名 | 臺灣獸醫學雜誌 |
卷期 | 38:2 2012.06[民101.06] |
頁次 | 頁67-74 |
分類號 | 437.25 |
關鍵詞 | 犬; 乳腺腫瘤; 管狀乳突瘤; Calponin; Canine; Mammary gland tumor; p63; Tubulopapillary carcinoma; |
語文 | 英文(English) |
中文摘要 | 管狀乳突癌在犬乳腺腫瘤中被報導是一種在單純型癌中預後最好的惡性腫瘤。針對p63和calponin,兩種肌上皮細胞的標誌進行免疫組織化學染色,在人類乳房腫瘤中,被證實在決定是否具有侵襲性相當有幫助。本研究收集19例原先診斷為管狀乳突癌的犬隻,進行p63和calponin 的免疫組織化學染色。19隻中有10隻顯示有被p63和calpinin所染上的肌上皮細胞圍繞在腫瘤周邊,且牠們皆未產生手術後復發或是遠端轉移。其他9隻則p63和calponin並未表現,故顯示有肌上皮細胞的缺少,且其中5隻產生遠端轉移或因癌症死亡。臨床症狀初次表現到病理診斷確診時間和存活時間在9隻缺少肌上皮細胞的犬中,皆明顯較短(P值分別是0.001和0.021)。根據上述研究,管狀乳突癌在犬乳腺腫瘤中,也許被過度診斷。在犬乳腺的管狀乳突瘤的困難診斷病例,針對p63和calponin進行免疫組織化學染色是一個相當推薦的病理診斷輔助工具。 |
英文摘要 | Tubulopapillary carcinoma is reported to have the best prognosis among the entity of simple carcinoma in canine mammary gland tumors. Immunohistochemical stain for p63 and calponin, described as myoepithelial cell markers, are helpful in determining the invasiveness of human breast tumors. Nineteen canine cases with original diagnosis of tubulopapillary carcinoma were selected for study of p63 and calponin. Ten of the selected 19 cases showed preserved myoepithelial cells highlighted by p63 and calponin staining surrounding the tumor cells and none of them developed recurrence or metastasis. The remaining 9 cases revealed loss of myoepithelial cells by negative staining for p63 and calponin and five of them developed metastasis or tumor-related death. The time of initial presence of clinical symptoms to pathological diagnosis and the survival time were also statistically lesser in the 9 cases without expression of p63 and calponin (Ρ= 0.001 and Ρ= 0.021, respectively). In conclusion, tubulopapillary carcinoma may be an over-diagnosed entity in canine mammary tumors. Immunohistochemical stain for p63 and calponin is recommended for difficult cases to determine the malignancy in canine mammary tubulopapillary tumors. |
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