查詢結果分析
來源資料
相關文獻
- Pemetrexed as Third-line Chemotherapy for Locally Advanced and Metastatic Non-small Cell Lung Cancer (NSCLC): A Retrospective Analysis
- 非小細胞肺癌術前輔助性化學治療的經驗
- The Role of Radiotherapy for Advanced Non-Small Cell Lung Cancer
- Differential Display of mRNA in Human Lung Tissue and in Non-Small Cell Lung Cancer: A Preliminary Report
- 非小細胞肺癌的治療
- 晚期非小細胞肺癌之化學治療
- CA405之基因療法合併化學抗癌藥物對肺癌細胞之作用效果評估與機轉的探討(2)
- Treatment of Non-Small-Cell Lung Cancer: The Chinese Experience in a General Teaching Hospital
- erbB基因與非小細胞肺癌的原發抗藥性
- Concurrent 5-Fluorouracil, Leucovorin, Etoposide, Cisplatin and Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer
頁籤選單縮合
題名 | Pemetrexed as Third-line Chemotherapy for Locally Advanced and Metastatic Non-small Cell Lung Cancer (NSCLC): A Retrospective Analysis=局部晚期及轉移性非小細胞肺癌使用Pemetrexed當作第三線化學治療之治療成效--回溯性分析 |
---|---|
作者 | 吳佳哲; 邱泰然; 林孟志; 王瑞隆; 饒坤銘; 陳彥仰; 黃承華; | 書刊名 | 臺灣癌症醫學雜誌 |
卷期 | 27:4 2011.08[民100.08] |
頁次 | 頁157-164 |
分類號 | 415.468 |
關鍵詞 | 非小細胞肺癌; 第三線化學治療; Non-small cell lung cancer; Pemetrexed; Third-line chemotherapy; |
語文 | 英文(English) |
中文摘要 | 背景:目前對於非小細胞肺癌並無標準的第三線化學藥物治療方式,本研究試圖評估pemetrexed當作第三線化學治療或之後的療效。 方法:回顧在兩線化學治療之後(不計標靶藥物),使用pemetrexed 當作第三線或之後時的病歷資料,並根據其第一線化學治療成效,分成「一直有效」、「打到沒效」、「一直沒效」三組來分析。 結果:總共有97位病人接受pemetrexed當作第三線或之後的化學治療。在第三線這組,反應率為4.5%,中值疾病惡化時間是2.8個月;在第四線之後,反應率為3.8%,中值疾病惡化時間是2.9個月。再次分析中,部分反應率的部分,在「一直有效」這組是8.1%,而「一直沒效」這組則是3.4%,但在「打到沒效」這組,則沒有部分反應率,在這三組中值疾病惡化時間則沒有統計學上的意義。 結論:pemetrexed當作第三線的化學治療應有一定的角色,而根據第一線化學藥物治療的效果,可能可以當作一個預測因子。 |
英文摘要 | Background: There are no drugs approved for third-line chemotherapy in non-small cell lung cancer(NSCLC) and no clinical trials to find an optimal third-line regimen. It is our intention to validate pemetrexed as third-line chemotherapy and to find predictors for a possible response group. Methods: Medical records of NSCLC patients who were administered pemetrexed when failing two lines of current chemotherapy were collected. In these patients, tyrosine kinase inhibitors were not counted in as a line of chemotherapy. We classified the status before pemetrexed into responsive, responsive-to-progression, and non-responsive groups, and tried to find predictors for pemetrexed responsiveness. Results: Ninety seven patients, who received pemetrexed as third-line chemotherapy or later, were eligible for analysis. In pemetrexed as third-line chemotherapy, the response rate was 4.5% and median TTP was 2.8 months; in fourth-line or later, the response rate was 3.8% and median TTP was 2.9 months. In responsive and non-responsive groups, partial response was 8.1% in the responsive group and 3.4% in the non-responsive group. No partial response was noted in responsive-to-progression group. There was no difference in median TTP between these three groups. Conclusions: When failing two lines of chemotherapy, pemetrexed still has a modest role as third-line chemotherapy. The response status to first-line platinum doublet might be predictive. However, a prospective study is needed to prove this hypothesis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。