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題名 | 結合熱均質與超音波技術製備奈米結構脂質載體=Preparation of Nanostructured Lipid Carriers by Combined Hot Homogenization and Sonication Technique |
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作者姓名(中文) | 鐘薇箮; 徐照程; | 書刊名 | 弘光學報 |
卷期 | 65 2011.12[民100.12] |
頁次 | 頁167-177 |
分類號 | 466.7 |
關鍵詞 | 奈米結構脂質載體; 固體脂質奈米粒; 熱均質乳化法; 超音波分散法; 結合技術; Nanostructured lipid carriers; NLC; Solid lipid nanoparticles; SLN; Hot homogenization; Sonication; Combined technique; |
語文 | 中文(Chinese) |
中文摘要 | 本研究選用天然固體脂質蜜蠟(Bees wax)及合成液態脂質辛酸/癸酸甘油酯(CCTG)為原料,結合熱均質與超音波技術製備新型固體脂質奈米粒(NLC)。本技術具有製備生產成本低廉、簡易快速及容易量產等優點。製程條件探討以平均粒徑為指標,觀察脂質種類、複合脂質比例、油水相比例、均質轉速及均質時間等製程參數對於NLC粒徑的影響。 結果顯示搭配超音波分散法全程保溫80℃,有助於粒徑分散達到製備小粒徑之目的,結合兩技術可使粒徑縮小34.60%。另一方面均質攪拌轉速越大,均質時間越長皆有助於粒徑趨小,在9000 rpm/40 min所製備的微粒奈米結構脂質載體(NLC)粒徑1.244 μm比3000 rpm/20 min粒徑3.046 μm縮小了59.15%,且粒徑分佈良好。另以熱重力分析證明其於130℃以下具有高熱穩定性。可知本研究製備之NLC足以作為包覆活性成分之理想載體。 |
英文摘要 | In this study, combined hot homogenization and sonication technique was employed to produce Nanostructured lipid carriers (NLC). Beeswax and caprylic/capric triglycerides (CCTG) were chosen as the solid lipid and liquid lipid. This novel technique offers advantages over the traditional techniques for lower running cost, simple operation and high yield production. The influences of mixed lipid composition, phase ratio of emulsion, homogenization speed and time on both particle size and other physicochemical properties of the NLC were characterized. As a result, this combined technique provides 34.60% particle size reduction with narrow particle size distributions behave. The size of nanostructured lipid carriers (NLC) was significantly influenced by homogenization speed and time. As 3000 rpm/20 min. homogenization condition increased up to 9000 rpm/40 min., the obtained particles showed pronounced 59.15% particle size reduction. Thermal property of NLC was studied by thermogravimetric analysis (TGA), 130℃thermal stability was observed on the TGA curves. These results indicated that the NLC in this study produced by combined technique under optimal conditions could potentially be exploited as a cosmetic active carrier with narrow particle size distribution and thermally stable properties. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。