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題 名 | Gastroprotective Effects of Ping-Wei San on Indomethacin-Induced Gastric Ulcer=平胃散對吲哚美洒辛引起胃潰瘍之保護作用 |
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作 者 | 張甄; 梁文俐; 劉湘吟; 王坤謄; 張君照; 王靜瓊; | 書刊名 | Journal of Food and Drug Analysis |
卷 期 | 19:4 2011.12[民100.12] |
頁 次 | 頁509-516+542 |
分類號 | 414.52 |
關鍵詞 | 平胃散; 吲哚美洒辛; 胃潰瘍; 抗發炎作用; Ping-Wei San; Indomethacin; Gastric ulcer; Anti-inflammation; |
語 文 | 英文(English) |
英文摘要 | Ping-Wei San (PWS), a Chinese medical decoction, was used to improve digestive absorption. This study was aimed to determine whether treatment with PWS reduce gastric ulceration induced by indomethacin and influencing its anti-inflammatory effect. PWS was extracted with boiling water and the decoction was freeze-dried into powder (H-PWS). The amounts of glycyrrhizin and hesperidin in H-PWS were analyzed by a HPLC method to be 38 and 19 mg/g, respectively. Co-administration of H-PWS resulted in a dose-dependent inhibition of indomethacin-induced gastric mucosal cell death. H-PWS (200 mg/kg) also alleviated the indomethacin-induced gastric ulcer in male Wistar rats in vivo. The inhibition effects of NO and PGE2 production were enhanced by indomethancin co-treatment with H-PWS from LPS-stimulated RAW 264.7 cells. H-PWS (200 mg/kg) also augmented the anti-inflammatory effect of indomethacin in 1% carrageen-induced paw edema. Moreover, H-PWS co-treatment with indomethacin produced a lower PGE2 level in serum than only indomethacin. Based on the results, co-treatment with H-PWS reduced the occurrence of indomethacin-induced gastric ulcers without affecting the anti-inflammatory effect of indomethacin. Therefore, we suggested that H-PWS can be developed as an anti-ulcer drug and H-PWS could be taken with indomethacin to decrease ulceration. |
本系統中英文摘要資訊取自各篇刊載內容。