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題名 | Preparation of a Naltrexone HCl Potentiometric Sensor and Its Application to Pharmaceutical Analysis and Drug Determination in Biological Fluids=製備電位差傳感器應用於藥物及生體液中Naltrexone HCl含量測定 |
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作者姓名(外文) | Fatemeh Ghorbani-Bidkorbeh; Saeed Shahrokhian; Ali Mohammadi; Rassoul Dinarvand; | 書刊名 | Journal of Food and Drug Analysis |
卷期 | 19:4 2011.12[民100.12] |
頁次 | 頁445-451+539 |
分類號 | 412.36 |
關鍵詞 | 離子選擇性電極; 直接電位法; 藥物分析; 生體液; Naltrexone HCl; Ion selective electrode; Direct potentiometry; Pharmaceutical analysis; Biological fluids; |
語文 | 英文(English) |
英文摘要 | A novel ion selective electrode is fabricated for naltrexone HCl and used in pharmaceutical analysis and drug determination in biological fluids without complicated pretreatments and extractions, using direct potentiometry. The naltrexone complex with sodium tetraphenyl borate (NaTPB) is obtained by in situ soaking PVC membrane electrode in an 1 × 10-3 M naltrexone solution. The sensor exhibited fast, reproducible and linear sub-Nernstian response over concentration range of 1 × 10-5 - 1 × 10-3 M with a detection limit of 5 × 10-6 M. The membrane sensor was successfully applied to the determination of naltrexone in capsules as well as for its determination in urine and plasma samples. |
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