頁籤選單縮合
| 題 名 | 液相層析質譜術在藥物分析之應用 |
|---|---|
| 作 者 | 沈振峰; 何國榮; | 書刊名 | 藥物食品分析 |
| 卷 期 | 3:4 1995.12[民84.12] |
| 頁 次 | 頁243-258 |
| 分類號 | 418.43 |
| 關鍵詞 | 液相層析質譜術; 藥物分析; Atmospheric ionization; LC/MS; Electrospray ionization; Atmospheric pressure chemical ionization; |
| 語 文 | 中文(Chinese) |
| 英文摘要 | Atmospheric ionization is the most important development for LC/MS in recent years. Two atmospheric pressure ionization methods, electrospray ionization (ESI) and atmospheric pressure chemical ionizatlon (APCI) are described. Electrospray is most suited to compounds of high polarity or thermolabile because ionization of electrospray is performed in solution, and vaporization of analyte before ionization is not necessary. The optimal flow rate of electrospray, in general, is in the range of 40-200 ul/min, although the upper limit is about 1 ml/min. Atmospheric pressure chemical ionization utilizes the constituent of mobile phase and water vapor as the reagent gas for chemical ionization. This method is best suited for compounds of low to medium polarity. APCI can take higher flow rate than ESI and it can directly couple with conventional 4.6mmID packed column (1-2 ml/min) without splitting. Two examples are used to illustrate the potential of using LC-API/MS system in drug analysis. |
本系統中英文摘要資訊取自各篇刊載內容。