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題 名 | 呼吸器CMV模式最佳送氣波形模擬與通氣實驗:以正弦波為例=Simulations and Experiments of Optimal Sinusoidal Airflow in the CMV Mode |
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作 者 | 林賢龍; 謝宏偉; 陳鉅強; | 書刊名 | 長庚科技學刊 |
卷 期 | 15 2011.12[民100.12] |
頁 次 | 頁161-178 |
分類號 | 415.41 |
關鍵詞 | 機械通氣; 控制通氣模式; 正弦波送氣氣流; 最佳化; 迴圈函數; Mechanical ventilation; CMV; Sinusoidal airflow; Optimization; Loop function; |
語 文 | 中文(Chinese) |
中文摘要 | 為使最小呼吸耗能實現於現有呼吸器,本研究以「最佳機化呼吸控制模型」作為基礎,使用CMV通氣模式、容積控制通氣下之正弦波送氣氣流做為設定指標,利用最佳化控制器與呼吸耗能最小化過程,模擬出機械通氣時之最佳正弦波送氣氣流與參數設定。研究結果並與POON's模式相較分析,在吸入二氧化碳與新陳代謝率增加,或連續性呼吸道阻抗與肺順應性等呼吸機械特性改變,最佳送氣波形與最佳通氣範型,均獲得相似特性結果。在最佳化模擬中所獲得的最佳正弦波送氣氣流與參數設定,進一步以NPB7200呼吸器,透過最佳化模擬人機介面、人工肺訊號監測軟體、訊號示波器、與人體呼吸控制模擬器等,對人工肺進行通氣實驗。在呼吸道阻抗及肺彈性等呼吸機械特性改變的實驗中,由壓力-容積及流速-容積迴圈函數的模擬與機械通氣結果發現,吸氣期與吐氣期變化趨勢,與文獻的臨床觀察結果相符。本研究除對智慧型人工呼吸器的控制提供另一方向的思考,未來將進一步對呼吸器各種送氣波形與參數設定進行較完整之最佳化研究,對於目前呼吸器與呼吸治療臨床應用價值將有助益。 |
英文摘要 | To develop a simulation and control mechanism for a mechanical ventilator of respiratory therapy, the control mode ventilation (CMV) was chosen for this research. The optimal respiratory control model, sinusoidal waveform, which is commonly utilized in clinical applications of volume-targeted approach, was modeled and optimized. To meet the needs for ventilation by considering both chemical and mechanical costs, the effort of breathing for a patient under mechanical ventilation is minimized. The simulations were performed and the resultant waveforms were examined in comparison with those of Poon’s model under various simulations of muscular exercise, CO2 inhalation, and resistive and elastic loading. Furthermore, the optimal sinusoidal waveform and ventilator setting were also applied on NPB 7200 with an artificial lung. The experiments of mechanical ventilation were compared with simulation results as the pressure-volume loops and flow-volume loops were investigated. Both the simulation and experimental results were found to agree with previous theoretical research and clinical observations. |
本系統中英文摘要資訊取自各篇刊載內容。