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題名 | 靈芝乙醇萃取物抗氧化與抗致突變性評估=Evaluation on Antioxidant Activity and Antimutagenicity of Ganoderma lucidum (Leyss ex. Fr.) Karst Ethanolic Extracts |
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作者 | 王子慶; 沈盈貝; 林麗娟; 蔡佳宏; 吳明昌; 林聖宗; Wang, Tzu-ching; Shen, Ying-pei; Lin, Li-chuan; Tsai, Chia-hung; Wu, Ming-chang; Lin, Shen-chung; |
期刊 | 大仁學報 |
出版日期 | 20110900 |
卷期 | 39 2011.09[民100.09] |
頁次 | 頁17-34 |
分類號 | 414.5 |
語文 | chi |
關鍵詞 | 靈芝; 抗氧化; 抗致突變性; Ganoderma lucidum (Leyss ex. Fr.)Karst; Antioxidant activity; Antimutagenic activity; |
中文摘要 | 本試驗利用多種抗氧化分析方法與Ames test,測試並評估靈芝乙醇萃取物 (Ganoderma lucidum (Leyss ex. Fr.) Karst ethanolic extract, GLEE)之體外抗氧化與抗致突變性。結果顯示:一、抗氧化方面:以 ferric thiocyanate method與conjugated diene method測試,於20 mg/mL濃度下,GLEE展現最高的總抗氧化能力(91.4%)與抗氧化活性(74.2%)。在以不同之催化因子所催化之脂質過氧化系統中, GLEE均會表現出不同程度之抗氧化性,並以在自氧化系統中有最佳之抗氧化性,且在各系統中,脂質過氧化抑制效果會隨著GLEE濃度之增加而增加。二、毒性試驗方面:對 TA98菌株, GLEE於未加S9 mix時,其5 mg/plate菌落數與對照組有顯著差異,表示其對菌株具毒性,但減至 2.5 mg/plate則不具毒性;對 TA100與TA1535二菌株則皆不具毒性。三、致突變性試驗方面:各 GLEE測試劑量對參試菌株均不具致突變性。四、抗致突變性試驗方面:當GLEE濃度為5 mg/plate時,當有 NQNO存在時,對TA98菌株有最佳的抗致突變性,抑制率可達到92%,而對 TA1535菌株的抗致突變性最差,抑制率可達到 81%;當有 B[a]P存在時,對 TA1535菌株有最佳的抗致突變性,抑制率可達到76%,而對TA100菌株的抗致突變性最差,抑制率僅可達到21%。 |
英文摘要 | The study was investigated the antioxidant and antimutagenic activity of Ganoderma lucidum (Leyss ex. Fr.) Karst ethanolic extract (GLEE) by several antioxidant activity determinated methods and Ames test. Results indicate that: 1. Antioxidant activity: Results indicated that the GLEE showed a high total antioxidant capacity (91.4%) with ferric thiocyanate method and exhibited the highest antioxidant activity (74.2%) with conjugated diene method at 20 mg/mL. The GLEE exhibited various degree of antioxidative activities and the linoleic acid peroxidation inhibition percentage of GLEE was increased with increasing concentrations at all different proxidants systems. The height inhibition was showed in the autoxidation system. 2. Toxic test: Non-toxicity was found in GLEE with or without S9 mix toward TA100 and TA1535 at the dosage of 5 mg/plate. Non-toxicity was also found in GLEE without S9 mix toward TA98 at 2.5 mg/plate. 2. Mutagenic test: Non-mutagenicity was found in GLEE with or without toward TA98, TA100 and TA1535. 3. Antimutagenic test: GLEE (at 5 mg/plate) showed the strongest inhibition effect toward TA98 against NQNO (the inhibition was 92%) and toward TA1535 (the inhibition was 76%) against B[a]P, but has lower exhibition effect toward TA1535 (the inhibition was 81%) against NQNO and toward TA100 (the inhibition was 21%) against B [a] P, respectively. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。