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| 題 名 | Mesaconitine Plays the Major Role in the Antinociceptive and Anti-Inflammatory Activities of Radix Aconiti Carmichaeli (Chuan Wu)=在川烏的鎮痛及抗發炎活性上新烏頭鹼扮演主要的作用 |
|---|---|
| 作 者 | 賴美州; 劉怡旻; 劉崇喜; 張永勳; | 書刊名 | Journal of Food and Drug Analysis |
| 卷 期 | 19:3 2011.09[民100.09] |
| 頁 次 | 頁362-368+380 |
| 分類號 | 414.33 |
| 關鍵詞 | 烏頭類生物鹼; 鎮痛活性; 抗發炎活性; 川烏; Aconitum alkaloids; Antinociceptive activity; Anti-inflammatory activity; Radix aconiti carmichaeli; Chuan Wu; |
| 語 文 | 英文(English) |
| 英文摘要 | ABSTRACT This study investigated the antinociceptive and anti-inflammatory activities of the aqueous extracts of Radix Aconiti Carmichaeli (Chuan Wu) by oral gavage in mice. Carrageenan-induced paw edema served as an acute inflammation model. The acetic acid-induced writhing test and formalin-induced nociceptive responses in the early and late phases were used to assess the analgesic activity. The contents of Aconitum alkaloids were analyzed by high-performance liquid chromatography. The order of concentration of aconitine-type alkaloids in Radix Aconiti Carmichaeli was mesaconitine > aconitine > hypaconitine. Radix Aconiti Carmichaeli water extract at the dosage of 60 mg/kg not only effectively inhibited carrageenan-induced paw edema, but also significantly attenuated the abdominal constriction induced by an intraperitoneal injection of acetic acid, as well as the late phase of pain response caused by a hindpaw injection of formalin. Mesaconitine and aconitine are effective in decreasing the pain sensation elicited by acetic acid. The aqueous extracts of Radix Aconiti Carmichaeli exhibits antinociceptive activity and anti-inflammatory effect probably due to the presence of high content of mesaconitine. |
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