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題 名 | 酸桔(Citrus sunki Hort)及扁實檸檬(Citrus depressa Hayata)果實萃取物對發炎生化指標的影響=Effects of the Sunki (Citrus sunki Hort.) and Hirami Lemon (Citrus depressa Hayata) Fruit Extracts on the Inflammatory Biomarkers |
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作 者 | 陳如茵; 蔡美珠; | 書刊名 | 臺灣農業化學與食品科學 |
卷 期 | 49:3 2011.06[民100.06] |
頁 次 | 頁118-130 |
分類號 | 435.33 |
關鍵詞 | 阿斯匹靈; 酸桔; 扁實檸檬; 果皮; 果肉; 抗發炎; 心血管疾病; 生化指標; Aspirin; Sunki; Citrus sunki Hort.; Hirami lemon; Citrus depressa Hayata; Peels; Pulp; Juice; Anti-inflammation; Cardiovascular disease; Biomarkers; |
語 文 | 中文(Chinese) |
中文摘要 | 本篇利用12-O-tetradecanoylphorbol-13-acetate (TPA)誘導老鼠耳朵持續發炎之模式,探討阿斯匹靈、酸桔 (Citrus sunki Hort.)果實和扁實檸檬(Citrus depressa Hayata)果實萃取物對發炎生化指標的差異。使用1.0 mg aspirin/ear塗抹於TPA誘發發炎的小鼠耳朵,對耳朵組織內血栓素(thromboxane B(subscript 2); TXB(subscript 2))抑制率為80.08%,且對前列腺素E(subscript 2) (prostaglandin E(subscript 2);PGE(subscript 2))、P-Selectin和VCAM-1(vascular cell adhesion molecule-1)分別顯著抑制111、50.23及73.14%(p<0.05)。然該劑量對TPA誘發之腫脹和與心血管疾病相關的生化指標如:白三烯素B(subscript 4) (leukotrienes B(subscript 4);LTB(subscript 4)、促發炎激素 (TNF-α、IL-1β、IL-6)、E-Selectin、ICAM-1、單核細胞趨化蛋白 (MCP-1) 和基質金屬蛋白酶 (MMP-9) 等則無顯著作用。使用相當於200 mg酸桔或扁實檸檬果皮凍乾粉末之乙酸乙酯萃出物塗抹耳朵,對TXB(subscript 2)抑制率分別為84.06及94.71%,與1.0 mg aspirin/ear作用相近。該劑量之酸桔果皮萃出物除對E-Selectin、P-Selectin無顯著抑制外,對腫脹、PGE(subscript 2)、LTB(subscript 4)、促發炎激素 (TNF-α、IL-1β、IL-6)、ICAM-1、VCAM-1、MCP-1和MMP-9等皆有顯著作用(p<0.05)。該劑量之扁實檸檬果皮萃出物則對上述生化指標都有顯著作用,顯然果皮萃出物對這些生化指標的作用比阿斯匹靈均衡。酸桔果肉或扁實檸檬果汁萃出物也具有抑制發炎指標的能力,只是作用劑量大,能作用的生化指標較少。扁實檸檬果皮經殺菁及漂水後,對其抗發炎能力影響不大。 |
英文摘要 | The inhibitory effects of aspirin, Sunki fruit extract and Hirami lemon fruit extract on inflammation were evaluated using a mouse model with the 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment to induce inflammation on ears. Topical application of 1.0 mg aspirin/ear significantly inhibited TPA-induced increase of thromboxane B(subscript 2) (TXB(subscript 2)), prostaglandin E(subscript 2) (PGE(subscript 2)), P-Selectin and VCAM-1 by 80.08, 111, 50.23 and 73.14% (p<0.05), respectively. The same treatment with the extract did not significantly inhibit TPA-induced edema and increase of the biomarkers associated with cardiovascular diceases, such as leukotriene B(subscript 4) (LTB(subscript 4)), proinflammatory cytokines (TNF-α, IL-1β and IL-6), E-Selectin, ICAM-1, MCP-1 and MMP-9. However, topical application of the extracts from 200 mg freeze-dried peels of Sunki (Citrus sunki Hort.) and Hirami lemon (Citrus depressa Hayata) significantly inhibited TPA-induced increase of TXB(subscript 2) levels by 84.06 and 94.71%, respectively. The effects were similar to that of 1.0 mg aspirin/ear. The extracts also significantly inhibited TPA-induced edema and increase of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), adhesion molecules (E-Selectin, P- Selectin, ICAM-1 and VCAM-1), MCP-1 and MMP-9 (p<0.05), except the extract of Sunki peel for E-Selectin and P-Selectin. In additional studies, there was also anti-inflammation effect in the extracts of Sunki pulps and Hirami lemon juice, but the effective dosages of the pulp and juice extracts were higher than peel extracts. The anti-inflammatory effect of the Hirami lemon peel extract was not affected after being blanched and leached. |
本系統中英文摘要資訊取自各篇刊載內容。