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頁籤選單縮合
題名 | 慢性骨髓性白血病=Chronic Myelogenous Leukemia |
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作者 | 陳玉美; 李建瑩; 蔡敏鈴; | 書刊名 | 藥學雜誌 |
卷期 | 27:2=107 2011.06[民100.06] |
頁次 | 頁85-89 |
分類號 | 415.635 |
關鍵詞 | 慢性骨髓性白血病; 費城染色體; 酪胺酸激酶抑制劑; Chronic myeloid leukemia; Philadelphia chromosome; Tyrosine kinase inhibitor; |
語文 | 中文(Chinese) |
中文摘要 | 慢性骨髓性白血病是一種骨髓增生性疾病,患者體內的白血球會出現不正常的增生現象, 90%以上之病人有費城染色體存在。未治療之平均存活時間為 3-5年。病程可分為三個階段: 1.慢性期 2.加速期 3.急性期。在慢性期可以容易的以藥物控制,主要目標為控制症狀及併發症並延緩進入加速期及急性期。治療方式有細胞毒藥物治療、酪胺酸激酶抑制劑治療及同種異體的造血細胞移植等。雖然唯一能治癒之治療是同種異體的造血細胞移植,然而藥物治療仍是多數病人的選擇。本文論述慢性骨髓性白血病之病因、發生率、臨床病程及藥物治療。 |
英文摘要 | Chronic myelogenous leukemia (CML) is a myeloproliferative disorder. Philadelphia chromosome can be found in 90% patients. CML has a triphasic clinical course: chronic phase, accelerated phase and blast crisis. In chronic phase, it is easy control with medicines. To control symptoms and complications is the major target. CML treatments include cytotoxic agents, Tyrosine kinase inhibitors and allogenic hematopoietic cell transplantation. Although transplantation is the only way to cure CML, most patients choose medical care. This article reviewed cause, pathology, clinical course and medical treatments. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。