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題名 | Evaluation of Exhaled Nitric Oxide in Patients with Sauropus Androgynus-Related Bronchiolitis Obliterans=評估吐氣之一氧化氮在守宮木引起之阻塞性細支氣管炎的表現 |
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作 者 | 歐亭芸; 沈協益; 賴瑞生; | 書刊名 | 胸腔醫學 |
卷期 | 26:3 2011.06[民100.06] |
頁次 | 頁120-126 |
分類號 | 415.426 |
關鍵詞 | 阻塞性細支氣管炎; 一氧化氮; 守宮木; Bronchiolitis obliterans; Nitric oxide; Sauropus androgynus; |
語文 | 英文(English) |
中文摘要 | 背景:台灣在民國84年時有爆發一波阻塞性細支氣管炎,經流行病學調查後發現與服用減肥菜-守宮木有關,本研究的目的在於了解一氧化氮在守宮木引起之阻塞性細支氣管炎所扮演之角色。方法:利用化學發光分析法測量吐氣之一氧化氮濃度。共有20位守宮木相關之阻塞性細支氣管炎,38位氣喘及10位健康的志願受測者接受測量。本實驗排除過敏性鼻炎及測量前6週有上呼吸道感染之病人。個案於肺功能檢測前即接受吐氣之一氧化氮檢測,共執行三次並取其平均值。結果:用力吐氣第一秒量(FEV1)於阻塞性細支氣管炎個案明顯低於氣喘組及健康受測者(<0.001),分別為阻塞性細支氣管炎組0.49±0.13L,氣喘組2.50±1.10L,及健康受測者2.26±0.64L(平均值±標準差)。阻塞性細支氣管炎之吐氣一氧化氮濃度較氣喘患者來的低(平均值:5.25 vs 8.40ppb, p=0.006),但與健康受測者則無差異(平均值:5.25 vs 5.35 ppb, p=0.843)。而吐氣之一氧化氮濃度與用力吐氣第一秒量在三組間皆無統計學上之相關性。結論:守宮木引起的阻塞性細支氣管炎其吐氣一氧化氮濃度並不若氣喘病人有上升現象,可能原因為:一)病人接受一氧化氮測量時皆處於穩定期;二)一氧化氮於守宮木引起的阻塞性細支氣管炎並無扮演重要角色;三)廣泛性呼吸道上皮細胞損傷導致一氧化氮合成減少。 |
英文摘要 | Background: In Taiwan, there was an outbreak of bronchiolitis obliterans (BO) in 1995. Based on an epidemiological study, the disease was associated with the consumption of a vegetable, Sauropus androgynus. The goal of this study is to determine whether nitric oxide (NO) plays a role in Sauropus androgynus-related BO. Methods: Twenty cases of Sauropus androgynus related-BO, 38 cases of asthma and 10 cases of healthy volunteers were included. Cases with upper respiratory tract infection in the most recent 6 weeks and allergic rhinitis were excluded. The exhaled nitric oxide (eNO) level was measured by an offline method, and the levels from 3 exhalations were analyzed immediately after the completion of the last exhalation. The exhaled NO was measured before spirometry or on different days, and was then calculated as the mean of 3 values. Results: The BO, asthma and healthy volunteer case numbers were 20, 38 and 10 individually. The youngest mean age was in the asthma group (37 years old), compared with the BO group (51 years old) and the healthy volunteers (51 years old). The male-to-female ratios in the 3 groups were 1/19, 27/11 and 4/6. There were no smokers in either the BO or healthy volunteer group, but there were 9 smokers among the 38 subjects with asthma. The forced expiratory volume in 1 second (FEV1) in the 3 groups (BO, asthma, healthy volunteer) were 0.49 ± 0.13, 2.50 ± 1.10 and 2.26 ± 0.64L (mean ± SD), respectively. FEV1 was significantly low in the BO group (p<0.001). The exhaled NO level was significantly lower in the BO subjects than in those with asthma (p=0.006), but without statistical difference from the healthy volunteers (p=0.843). The eNO level did not correlate with FEV1 among the 3 groups. Conclusions: The eNO level was not elevated in the subjects with Sauropus androgynusrelated BO; however, it was significantly elevated in the asthma subjects, as in other reports. The possible reasons may be: 1) The eNO level does not elevate in stable patients with Sauropus androgynus-related BO. 2) NO plays an insignificant role in the pathogenesis of Sauropus androgynus-related BO. 3) There was extended damage to the epithelial cells, the main production site of eNO. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。