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題 名 | Clinical Applications of VEGF-Trap (Aflibercept) in Cancer Treatment=VEGF-Trap(阿利西普)在腫瘤治療的臨床應用 |
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作 者 | 滕理送; 金科濤; 何奎鋒; 章靜; 王浩浩; 曹江; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 73:9 2010.09[民99.09] |
頁 次 | 頁449-456+CA82 |
關鍵詞 | 血管生成; 抗血管生成藥物; 臨床應用; VEGF-Trap; Angiogenesis; Antiangiogenic agent; Clinical application; |
語 文 | 英文(English) |
英文摘要 | Angiogenesis is one of the key acquired characteristics or “hallmarks” essential for the growth and development of all solid tumor types. The antiangiogenic agent vascular endothelial growth factor-Trap (VEGF-Trap) (aflibercept), which is a composite decoy receptor based on VEGF receptor-1 and VEGF receptor-2 fused to an Fc segment of immunoglobulin G1 that binds specifically to VEGF, has demonstrated preclinical efficacy in a range of different tumor types. VEGF-Trap exerts its antiangiogenic effects through regression of tumor vasculature, remolding or normalization of surviving vasculature, and inhibition of new tumor vessel growth. Preclinical and clinical studies have reported that VEGF-Trap can be combined effectively with both chemotherapy and radiotherapy. This review examines the main effects of VEGF-Trap on tumor vasculature and on different types of solid tumors, and explores the preclinical and clinical benefits of incorporating VEGF-Trap into anticancer treatment strategies. |
本系統中英文摘要資訊取自各篇刊載內容。