頁籤選單縮合
題 名 | Advances in Combination of Antiangiogenic Agents Targeting VEGF-binding and Conventional Chemotherapy and Radiation for Cancer Treatment=VEGF標靶抗血管生成藥物聯合傳統放化療抗腫瘤治療進展 |
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作 者 | 滕理送; 金科濤; 何奎鋒; 王浩浩; 曹江; 俞德超; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 73:6 2010.06[民99.06] |
頁 次 | 頁281-288+CA51 |
關鍵詞 | 抗血管生成藥物; VEGF標靶藥物; Bevacizumab; VEGF-Trap; Antiangiogenic agents; VEGF-targeted agents; |
語 文 | 英文(English) |
英文摘要 | Despite great efforts and resources being devoted to treatment, the incidence and mortality of numerous cancers have not decreased in recent decades. This is a result of the resistance of cancer cells to chemotherapeutic agents and radiotherapy. The development of antiangiogenic agents that target vascular endothelial growth factor (VEGF) provides a new option for treatment of cancer. Major advances have been achieved with cancer therapy based on antiangiogenic VEGFtargeted agents in the past few years, and some of the recently approved therapies are now being used in daily clinical practice. A further challenge is finding a more efficacious combination of antiangiogenic VEGF-targeted therapies and conventional radio- and chemotherapies. This review outlines the current preclinical and clinical cancer treatments using optimized combinations of antiangiogenic VEGF-targeted agents and conventional radiochemotherapy and highlights that better scheduling for the combination of radiochemotherapy and antiangiogenic VEGF-targeted agents should be developed to achieve better treatment outcomes. |
本系統中英文摘要資訊取自各篇刊載內容。