查詢結果分析
相關文獻
- Dexamethasone Inhibits Tumor Necrosis Factor-alpha-stimulated Gastric Epithelial Cell Migration
- 類固醇與消化性潰瘍
- 僵直性脊椎炎之治療
- Acute Retinal Necrosis-Early Manifestation and Successful Treatment with Steroid and Acyclovir: Case Report
- 粗製巴斯德桿菌D型毒素誘發腫瘤壞死因子-α產生與豬萎縮性鼻炎關係之探討
- Eosinophilic Cystitis and Ureteritis after Radical Prostatectomy: Case Report and Literature Review
- 非類固醇類消炎藥--選擇性COX-2抑制劑
- Detection of Tumor Necrosis Factor-α and Receptors in the Serum and Synovial Fluid of Patients With Rheumatoid Arthritis and Osteoarthritis
- 第一型介白質受體對抗劑和腫瘤壞死因子結合蛋白對去卵巢後骨質減少的效果
- 口服Ketorolac臨床安全性評估
頁籤選單縮合
題 名 | Dexamethasone Inhibits Tumor Necrosis Factor-alpha-stimulated Gastric Epithelial Cell Migration=類固醇抑制腫瘤壞死因子所刺激之胃上皮細胞移行 |
---|---|
作 者 | 羅景全; 曹之憲; 吳嘉敏; 項國威; 盧俊良; 陳增興; 張扶陽; 林漢傑; 彭清霖; 李壽東; | 書刊名 | Journal of the Chinese Medical Association |
卷 期 | 72:10 2009.10[民98.10] |
頁 次 | 頁509-514+CA96 |
分類號 | 418.2216 |
關鍵詞 | 細胞移行; 環氧化酶二; 類固醇; 胃潰瘍癒合; 腫瘤壞死因子; Cell migration(restitution); Cyclooxygenase-2; Dexamethasone; Gastric ulcer healing; Tumor necrosis factor-α; |
語 文 | 英文(English) |
英文摘要 | Background: Cell migration (restitution) occurs in the early phase of gastric ulcer healing. Tumor necrosis factor (TNF)-α is overexpressed at the ulcer margin and plays a physiologic role in gastric ulcer healing. Dexamethasone, which is a potent corticosteroid, delays rat gastric ulcer healing. We evaluated whether dexamethasone inhibited TNF-α-stimulated gastric epithelial cell migration using a rat normal gastric epithelial cell line (RGM-1). Methods: An artificial wound model was employed to measure cell migration. Western blot was performed to evaluate the possible mechanisms. Intracellular prostaglandin E2 level was measured using an enzyme-linked immunosorbent assay. Results: TNF-α treatment (10 ng/mL) for 12–48 hours significantly increased RGM-1 cell migration, and TNF-α treatment increased cyclooxygenase (COX)-2 protein expression 8 hours later and prostaglandin E2 (PGE2) synthesis 12 hours later compared with control (p < 0.05). Dexamethasone (10–6 M) significantly inhibited the stimulatory effect of TNF-α on RGM-1 cell migration, which was associated with a significant decrease in COX-2 expression and PGE2 level in cells (p < 0.05). Conclusion: TNF-α plays a regulatory role in rat gastric epithelial cell migration and dexamethasone inhibited TNF-αstimulated cell migration, which was associated with a decrease in COX-2 expression and PGE2 formation. |
本系統中英文摘要資訊取自各篇刊載內容。