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題 名 | Coexistence of the Increasing Oxidative Stress and the Clinical Severity of Patients with Oral Cavity Cancer=探討氧化性傷害與口腔癌病人臨床癌症分期的相關性 |
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作 者 | 吳思賢; 蔡世盟; 李家和; 陳建宏; 馬旭; 蔡麗玉; | 書刊名 | 臺灣整形外科醫學會雜誌 |
卷 期 | 19:2 2010.06[民99.06] |
頁 次 | 頁104-113 |
分類號 | 416.94 |
關鍵詞 | 氧化性傷害; 口腔癌; Oral cavity cancer; Oxidative stress; Glutathione status; Malondialdehyde; Antioxidative enzymes; |
語 文 | 英文(English) |
中文摘要 | 背景: 有研究報告指出口腔癌的形成與氧化性傷害有明顯的相關,但對於口腔癌臨床實際的嚴重程度與氧化性傷害的輕重是值得更深入探討的。 目的及目標: 希望介由本研究來瞭解口腔癌病人癌症分期與其氧化性傷害輕重的相關性。 材料及方法: 以116位男性病人經病理切片確診為口腔癌且具有不同癌症分期,及以122位健康男性作為對照組,抽血測定其體內malondialdehyde (MDA)、superoxide dismutase (SOD)、glutathione peroxidase (GPx)、glutathione reductase (GRx)、reduced glutathione (GSH)及oxidized glutathione (GSSG)的濃度變化;並以統計方法分析與癌症分期之相關性。 結果: 口腔癌病人血液內之GSH、GSSG及total GSH濃度與對照組相較有明顯的降低。相反的,MDA濃度與GSH/GSSG比值有明顯的上升。此外,MDA,SOD的活性及GRx在口腔癌病人有明顯的增加;然而GPx是相反的。在不同癌症分期的口腔癌病人,對於前述的氧化性傷害因子,在統計學上均有明顯的變化。 結論: 本實驗證實與其他研究報告結果吻合,口腔癌病人所受到的氧化性傷害較健康人為重;而且在癌症分期也與氧化性傷害有直接的正相關性。將來可考慮近一步的研究有關是否可以使用抗氧化藥物來減緩癌症的進展。 |
英文摘要 | Background: Even though oxidative stress has been reported to be associated with the development of oral cavity cancer, there is little evidence to show whether patients with more clinical severity suffer from more oxidative stress. Aim and Objectives: We would like to find out the coexistence of the increasing oxidative stress and the clinical severity of patients with oral cavity cancer. Materials and Methods: We launched this study to assess changes of the oxidant statuses, including malondialdehyde (MDA), the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRx) and glutathione status, including reduced glutathione (GSH) and oxidized glutathione (GSSG), in patients with oral cavity cancer at various clinical stages. Blood samples of 116 male biospy-proven and untreated patients with oral cavity cancer at various clinical stages (from stage Ⅰ to stage Ⅳ) and 122 male healthy controls were obtained. Results: The levels of GSH, GSSG, and total GSH were significantly decreased in the patients in comparison with those of the controls. Conversely, MDA levels and GSH/GSSG were significantly increased. Additionally, MDA, the activities of SOD, and GRx were significantly elevated in the patients, while the activity of GPx was reversed. There were significant changes in the aforementioned parameters in the linear contract test from stage Ⅰ to stage Ⅳ. Conclusions: This study reveals that patients with oral cavity cancer suffered from excessive oxidative stress, which was consistent with other previous studies; moreover, oxidative stress will aggravate as the disease progresses. |
本系統中英文摘要資訊取自各篇刊載內容。