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題 名 | 天然抗氧化物之經皮輸藥系統研究:以白藜蘆醇及大豆異黃酮為例=Topical/Transdermal Drug Delivery System for Natural Antioxidants: Resveratrol and Soy Isoflavones |
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作 者 | 黃梓柔; 陳志杰; 方嘉佑; | 書刊名 | 長庚科技學刊 |
卷 期 | 11 2009.12[民98.12] |
頁 次 | 頁1-9 |
分類號 | 418.1 |
關鍵詞 | 天然抗氧化劑; 白藜蘆醇; 大豆異黃酮; 經皮吸收; Natural antioxidants; Resveratrol; Soy isoflavones; Percutaneous absorption; |
語 文 | 中文(Chinese) |
中文摘要 | 白藜蘆醇(resveratrol)爲一天然多酚類化合物,存在於葡萄、紅酒、虎杖、覆盆子、桑椹、與花生中,它對於預防心血管疾病、紫外線所造成之皮膚傷害、抗發炎及癌症預防有良好的藥理活性,白藜蘆醇也具有對抗病毒之能力,此外它也具有抗氧化、抗老化、美白等功能,雖然白藜蘆醇具有許多好處,但是白藜蘆醇有難溶於水,以及口服代謝快速等缺點,對於需要維持長期血漿中有效濃度之情況下,白藜蘆醇可以說是非常不適合以口服方式投與,因此,在生體内試驗中白藜蘆醇的效果通常不如在生體外試驗中來得優秀。然而若以注射方式投與,因爲其爲侵入性之方法,做爲預防層面而言接受度亦不高,故使得白藜蘆醇之有效性無法良好發揮;而大豆異黃酮(isoflavones)此一酚類雌性激素(phenolic estrogens),具有防癌、預防骨質疏鬆、預防心血管疾病、降低血脂防、緩解更年期不適及皮膚美白等功效,因此我們的研究方向在於利用經皮輸藥系統(topical/transdermal drug delivery system, TDDS)投與白藜蘆醇及大豆異黃酮中之活性成份genistein,daidzein和glycitein,避免胃腸道受到損傷和肝臟首渡代謝效應(first-pass metabolism),使白藜蘆醇及大豆異黃酮之作用能有效發揮。綜合上述,本回顧性文章以TDDS方式投與白藜蘆醇及大豆異黃酮,針對他們在局部皮膚的活性與穿透途徑的效益做一系列探討。 |
英文摘要 | Resveratrol is one of the polyphenols from grapes, red wines, and peanuts. Its pharmacological effects have been shown on cardiovascular diseases, ultraviolet (UV)-induced skin damage, antiinflammation, and chemoprevention. Furthermore, it has anti-oxidation, anti-ageing, and skin-whitening effects. Although resveratrol is beneficial to health, it is not suitable to take orally because of the slow solubility in water and low oral bioavailability. That is to say its in vivo activity effect is much lower than that of its in vitro status. Parenteral route is also unsuitable for resveratrol because its aim is prevention rather than therapy. Soy isoflavones including genistein, daidzein, and glycitein are other great natural antioxidants with poor oral efficiency. Topical/transdermal drug delivery system (TDDS) was applied to deliver resveratrol and soy isoflavones to avoid low bioavailability by oral route, and to increase the activity in the in vivo or clinical condition. The purpose of this review article is to demonstrate skin permeation of resveratrol and soy isoflavones using examples for skin delivery of natural antioxidants. |
本系統中英文摘要資訊取自各篇刊載內容。