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題名 | Age-Related Reference Levels of Serum Prostate-Specific Antigen among Taiwanese Men without Clinical Evidence of Prostate Cancer=臺灣無前列腺癌的男性前列腺特異指數依年齡分布的參考值 |
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作者 | 林國仁; 馮思中; 張英勛; 吳俊德; 莊昆隆; 莊恆彰; 莊正鏗; | 書刊名 | 長庚醫誌 |
卷期 | 33:2 2010.03-04[民99.03-04] |
頁次 | 頁182-187 |
分類號 | 416.275 |
關鍵詞 | 年齡; 前列腺特異指數; 前列腺癌; 臺灣人; Age; Prostate-specific antigen; Prostate cancer; Taiwanese; |
語文 | 英文(English) |
中文摘要 | 2006 2007 4.0 ng/ml 4 ng/ml 20 ng/ml 7803 50- 59 ( 95 ) 0.896 ng/ml (3.329 ng/ml )-69 1.151 ng/ml (5.114 ng/ml)-79 1.623 ng/ml (6.237 ng/ml) 1.754 ng/ml (6.613 ng/ml) (r = 0.3078, p < 0.001) 50 95 50 |
英文摘要 | Background: To determine the normal distribution of serum prostate-specific antigen (PSA) levels in Taiwanese men without clinical evidence of prostate cancer. Methods: Between August 2006 and October 2007, healthy Taiwanese men undergoing a routine health examination in our hospital were recruited into the study. All men received a digital rectal examination (DRE) and serum PSA determination and some received a transrectal ultrasound (TRUS). Men with normal DRE findings, and PSA < 4.0 ng/ml, PSA between 4.0 ng/ml and 20 ng/ml with a negative TRUS or abnormal TRUS findings (hypoechoic lesion or others) with a negative biopsy were defined as clinically free of prostate cancer. Results: A total of 7803 participants without clinical evidence of prostate cancer were included in the study. The median PSA value (95th percentile range) was 0.896 ng/ml (3.329) for men 50-59 years old; 1.151 ng/ml (5.114) for men 60-69 years old; 1.623 ng/ml (6.237) for men 70-79 years old and 1.754 ng/ml (6.613) for men older then 80 years. The serum PSA values correlated with age (r = 0.3078, p < 0.001). There were small changes in the median and 95th percentile PSA values in men younger than 50 years old, but large increases in those older than 50 years. Conclusions: These findings confirm that the serum PSA is directly correlated with age, and offer more efficient PSA reference values for prostate cancer screening tests in Taiwanese men. |
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