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題 名 | Mefenamic Acid 導致罕見的肝細胞混合膽汁鬱積性肝炎及史帝文生強生症候群 : 一病例報告=Mefenamic Acid Induce Mixed Type Hepatocellular-Cholestatic Hepatitis and Stevens-Johnson Syndrome : Report of A Case |
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作 者 | 張仁鴻; 郭樂明; 賴豐傑; 陳勝咸; 孫啟書; 莊世松; 張聖宗; 王建楠; | 書刊名 | 內科學誌 |
卷 期 | 21:1 2010.02[民99.02] |
頁 次 | 頁66-71 |
分類號 | 418.2216 |
關鍵詞 | 藥物導致的肝臟損傷; 膽汁鬱積性肝炎; 史帝文生強生症候群; Drug-induced liver injury; Cholestatic hepatitis; Stevens-Johnson syndrome; Mefenamic acid; |
語 文 | 中文(Chinese) |
中文摘要 | 非類固醇抗發炎藥物 (nonsteroidal anti-inflammatory drugs,NSAIDs) 是一種很常用來解熱鎮痛抗發炎的藥物。過去的文獻裡,鮮少有提到fenamates 類NSAIDs (例如:mefenamic acid) 引起慢性肝細胞混合膽汁鬱積性肝炎合併史帝文生強生症候群 (Stevens-Johnson Syndrome,SJS) 的記載。NSAIDs 引起嚴重的藥物導致肝臟損傷 (drug-induced liver injury, DILI) 發生率不高。SJS 是一種不常見但卻是急性且可能致命的皮膚黏膜疾病,大部分均因藥物所引起,包括NSAIDs 。我們報告一個mefenamic acid 導致SJS 合併肝功能異常長達十一個月的慢性肝細胞混合膽汁鬱積性肝炎之罕見病例,同時藉由回顧文獻來探討引起這個現象的病理機轉、NSAIDs 與DILI 和SJS 兩者的關係、治療以及藥物基因體學 (pharmacogenomics) 的相關研究。 |
英文摘要 | Nonsteroidal anti-inflammatory drugs(NSAIDs) is frequently available for pain relief, antipyretic and antiinflammation. The fenamate class of NSAIDs, like mefenamic acid, inducing mixed type hepatocellularcholestatic hepatitis and Stevens-Johnson syndrome(SJS)was rarely mentioned in the previous papers. The incidence of serious NSAIDs-induced liinjury was not high. SJS is an uncommon but an acute fatal cutaneous mucosal disease that was often i nducedbvery medicine, such as NSAIDs. We herein report a 42-year-old man with mefenamiid-induced chronic mixed type hepatocellular-cholestatic hepatitis presented abnormality of liver function for el ecacven months, and SJS. We also briefly reviewed the literature associated with its pathogenesis, the relationship of NSAIDs with drug-induced liver injury and SJS, its treatment, and further discussed the pharmacogenomicology of disease. |
本系統中英文摘要資訊取自各篇刊載內容。