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頁籤選單縮合
| 題 名 | Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Retrospective Analysis of Southern Taiwanese Population during 2002 to 2007=史帝文強生症候群及毒性表皮溶解症:南臺灣病人流行病學回溯性研究 |
|---|---|
| 作 者 | 黃菁馨; 何宜承; 鄭裕文; 吳唯銘; 黃晟霖; 王振宇; | 書刊名 | 中華皮膚科醫學雜誌 |
| 卷 期 | 27:1 2009.03[民98.03] |
| 頁 次 | 頁15-26 |
| 分類號 | 415.7 |
| 關鍵詞 | 史帝文強生症候群; 毒性表皮溶解症; Stevens-Johnson syndrome; SJS; Toxic epidermal necrolysis; TEN; Clinical outcome; Systemic steroid; |
| 語 文 | 英文(English) |
| 英文摘要 | Background: Stevens-Johnson syndrome(SJS) and toxic epidermal necrolysis(TEN) are severe adverse drug reaction with potentially life-threatening skin disease. The widely accepted consensus regarding therapy does not exist at present and epidemiological data of Taiwan in recent years is limited. Objective: To evaluate the effi cacy of systemic steroid therapy in treatment of SJS and TEN and also analysis the associated epidemiology data. Methods: This study was performed by retrospectively chart review of patients admitted with SJS or TEN in a tertial referral medical center in southern Taiwan between 2002 and 2007. Clinical data including mortality, morbidity, the category of offending drugs and the systemic steroid treatment effects were analyzed. Results: Total 52 patients were included; 10 were classifi ed as TEN and 42 as SJS. Overall mortality is 3.8% and infectious morbidity is 23%. In aspect of causative agents, anticonvulsants (especially carbamazepine) were the most common drugs followed by Non-Steroid Anti-infl ammatory Drugs, allopurinol and antibiotics in our series. Early systemic steroid administration may shorten the hospitalization duration than supportive care (p < 0.012) in our study. Conclusion: In our study, early administration of systemic steroids maybe benefi ts in the forms of infl ammation prevention and disease progression. Short-term use to preclude infection morbidity, as well as a tapering dose as soon as possible, is suggested. |
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