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題 名 | Pharmacodynamic Evaluation of Terminalia bellerica for Its Antihypertensive Effect=Terminalia bellerica對於抗高血壓功效之藥物動力學評估 |
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作 者 | Khan, Arif-ullah; Gilani, Anwarul Hassan; | 書刊名 | 藥物食品分析 |
卷 期 | 16:3 2008.06[民97.06] |
頁 次 | 頁6-14+90 |
分類號 | 418.221 |
關鍵詞 | 抗高血壓; 抗Ca++; Terminalia bellerica; Antihypertensive; Ca++ antagonist; |
語 文 | 英文(English) |
英文摘要 | Terminalia bellerica has been used as a folk medicine in a variety of ailments including hypertension. Our aim was to investigate the possible mechanism of its blood pressure (BP)-lowering effect. The crude extract of Terminalia bellerica fruit (Tb.Cr) which tested positive for flavonoids, sterols and tannins induced a dose-dependent (10-100 mg/kg) fall in the arterial BP of rats under anaesthesia. In isolated guinea-pig atria, Tb.Cr inhibited the force and rate of atrial contractions. In rabbit thoracic aorta, Tb.Cr relaxed the phenylephrine (PE, 1 μM) and K+ (80 mM)-induced contractions as well as suppressed the PE (1 μM) control peaks in the Ca++-free medium, similar to that caused by verapamil. The vasodilator effect of Tb.Cr was endothelium-independent as it was not opposed by Nω-nitro-L-arginine methyl ester in endothelium-intact rat aortic preparations and it occurred at the similar concentration in the endothelium-denuded tissues. These results indicate that Terminalia bellerica lowers BP through Ca++ antagonist mechanism and thus provides a sound mechanistic background for its medicinal use in hypertension. |
本系統中英文摘要資訊取自各篇刊載內容。