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題 名 | 加拉加斯醯胺--新穎抗高血壓劑=A Novel Antihypertensive Agent |
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作 者 | 李安榮; 林康媺; 黃文鑫; 陳秀和; | 書刊名 | 醫學研究 |
卷 期 | 14:6 1994.05[民83.05] |
頁 次 | 頁357-370 |
分類號 | 418.221 |
關鍵詞 | 加拉加斯醯胺; 加拉加斯菊; 抗高血壓劑; Caracasanamide; Verbesina caracasana; Antihypertensive agent; |
語 文 | 中文(Chinese) |
中文摘要 | 加拉加斯醯胺(caracasanamide)是由菊科植物加拉加斯菊(Verbesina caracasana)單離出之降血壓活性成分。本品為1-[(3, 4-二甲氧桂皮醯基)胺基]-4-[(3-甲基-2-丁烯基)-胍基]丁烷之Z及E式混合物,其中Z式為水溶。加拉加斯醯胺具有明顯的降血壓活性,且能興奮呼吸,增加呼吸頻率及潮氣容積,增強心肌收縮力,但反射心跳加速副作用輕微。本藥影響心血管功能的之機轉為:(一)、作用於血管,致使動脈血管舒張;(二)、作用於中樞,減少交感神經活性:(三)作用於心臟β-1受體。加拉加斯醯胺之降壓活性比guanethidine更強,而與蛇根□(reserpine)及罌粟□(papaverine)約略相等。本藥藥效強,毒性低且作用期限長,為新穎之降血壓藥。 |
英文摘要 | Caracasanamide is one of the hypotensive agents iaolated from Verbesina caracasma. It is the mixture of E/Z forms of 1-[3,4-dimethoxycinnamoyl)amino]-4-[(3-methyl-2-butenyl)guanidine]butane. At nontoxic dose, Z-caracasanamide possesses significant, in vivo, activity of antihypertension with a lasting duration. Z-Caracasanamide was found to decrease blood pressure and to increase cardiac inotropism, respiratory frequency, and tidal volume, and to induce a very slight and not significant tachycardia. The pharmacological profiles indicate that the cardiovascular actions of this compound might result from: (a) a decrease in sympathetic outflow through central neurogenic mechanisms; (b) arterial vasodilation; and, (c) an interaction with the cardiac β-1 adrenoreceptors. Z-Caracasanamide is as effective as reserpine in lowering blood preseure and demonstrates a long duration than guanethidine, papaverine, histamine, and thus is a candidate in clinical application. This paper deals with the origin, structure, synthesis, pharmacological actions, and advantages of actions of caracasanamide. |
本系統中英文摘要資訊取自各篇刊載內容。