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題 名 | 正子造影卵巢氟-18-FDG攝取與月經週期之研究=Physiological 18F-FDG Uptake of Ovary during Menstrual Cycle in PET/CT |
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作 者 | 江泰林; 陳遠光; 葉加祿; 王素貞; 潘恆新; 柴發順; 吳宛儒; 周宣宏; 沈業有; 廖健發; 蘇誠道; | 書刊名 | 核子醫學雜誌 |
卷 期 | 19:2 民95.06 |
頁 次 | 頁71-76 |
分類號 | 417.124 |
關鍵詞 | 正子斷層造影; 月經週期; 卵巢; 排卵; 18F-FDG; PET/CT; 18F-FDG; Menstruation; Ovarian; Ovulation; |
語 文 | 中文(Chinese) |
中文摘要 | 背景:正子放射斷層掃描(positron emission tomography; PET)為臨床上一個重要的診斷工具,醫者必須暸解氟-18氟化去氧葡萄糖(18F-fluorodeoxyglucose;18F-FDG)在體內正常生理及良性病變分佈,才不會與惡性腫瘤產生混淆。婦女的正子造影發現卵巢有18F-FDG攝取,可懷疑為腫瘤細胞的代謝,但也有可能是正常生理性吸收造成的偽陽性。本研究旨在評估卵巢之18F-FDG攝取是否與女性月經週期相關。 方法:回溯本院進行18F-FDG PET/CT造影中,60例健康受檢者卵巢出現18F-FDG攝取,平均年齡41.2±5.9歲。本研究把卵巢生理週期分為月經期、濾泡期、排卵期、黃體期四個階段,分析其四組結果。 結果:60位受檢者在卵巢生理週期四個階段分佈人數和攝取18F-FDG的SUV(下标 max)值,在月經週期0例,濾泡期3例,平均SUV(下标 max)4.39±0.30;排卵期25例,平均SUV(下标 max)4.37±1.38;黃體期32例,平均SUV(下标 max)4.37±1.43。36例卵巢18F-FDG攝取在右邊,23例卵巢18F-FDG攝取在左邊,1例雙側卵巢18F-FDG攝取。 結論:小於50歲未停經婦女正子造影檢查卵巢有18F-FDG攝取,卵巢的生理週期在排卵期和黃體期之間,卵巢大小正常且CA-125在正常範圍,應可認為卵巢是正常生理性吸收。反之,停經後婦女正子造影檢查卵巢有18F-FDG攝取,應建議做進一步的檢查。月經週期的日期可以排除生理現象造成的偽陽性,可以做為輔助醫師診斷的重要參考。 |
英文摘要 | Background: Positron emission tomography (PET) is an important diagnostic tool in clinical application. For the diagnosis of malignant tumor by FDG-PET scan, the normal physiological distribution and benign pathology of FDG uptake must be understood. Increased FDG accumulation in the ovaries, if shown by FDG-PET images of women, may be associated with normal physiological uptake of ovary or tumor uptake. The purpose of this study is to assess the correlation between ovarian FDG uptake and menstrual cycle of women. Methods: Sixty healthy premenopausal woman examinees (mean age 41.2±5.9) whose FDG-PET images showed ovarian uptake in the menstrual cycle were enrolled retrospectively in this study. The menstrual cycle was divided into four stages: menstruation, follicular phase, ovulation, and luteal phase. We analyzed imaging results based on various stages. Results: Among 60 women with ovarian FDG uptake in the menstrual cycle, none in menstruation period, 3 in follicular phase (average SUV(subscript max); 4.39±0.30), 25 in ovulation period (average SUV(subscript max): 4.37±1.38), 32 in luteal phase (average SUV(subscript max): 4.37±1.43). Thirty-six women have ovarian uptake on the right side, 23 on the left side, and 1 on both sides. Conclusion: Increased FDG accumulation in the ovary of premenopausal women especially during the ovulation and luteal phases of menstrual cycle, if combined with normal size and CA-125 level, can be considered normal physiological ovarian uptake. On the other hand, further examination in concern for malignancy should be advised if increased FDG uptake is shown in the ovary of a post-menopausal woman. Inquiring and recording the menstrual history of the women referred for FDG-PET study is helpful to imaging diagnosis and also avoiding false-positive results. |
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