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題名 | Experiences and Literature Reviews to Inquire about The Dimensions of Prostate Specific Antigen and Its Applications=前列腺專一抗原內涵及其臨床應用趨勢:經驗及文獻回顧 |
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作者 | 蔡道桂; 彭南靖; | 書刊名 | 核子醫學雜誌 |
卷期 | 19:1 民95.03 |
頁次 | 頁37-44 |
分類號 | 415.863 |
關鍵詞 | 前列腺專一抗原; 腫瘤標記; 放射免疫分析; Prostate-specific antigen; Tumor marker; Radioimmunoassay; |
語文 | 英文(English) |
中文摘要 | 在我們的放射免疫分析實驗室,每年平均有110,000人次的血液標本因為需要篩檢或疾病診斷做前列腺專一抗原測定(PSA test),這說明PSA測定,是一種臨床上,尤其對泌尿科醫師而言更是喜愛並優先選用的檢查項目,在泌尿科門診,超過50歲的病人都會安排做PSA檢測。從過去相關的文獻報導,PSA被認為是一種強而有力的前列腺腫瘤標記。直到目前PSA對前列腺而言,其專一性是不錯的,但對前列腺癌則不盡然,因為PSA值升高也可見於前列腺相關疾病,諸如良性前列腺肥大,前列腺發炎,甚至與前列腺癌毫不相關的疾病像乳癌,這個事實與衝擊已無可避免的降低了PSA對前列腺癌測定的臨床價值。適當並謹慎地使用PSA與有效的檢測前列腺癌,並如何避免它在其他相關疾病被濫用,對我們來說確是一個嚴肅的課題。儘管PSA的愛用與爭議,一直存在多年,進一步的相關研究來認識PSA的內涵及重新評估它的臨床應用趨勢是確實需要的。 |
英文摘要 | In our radioimmunoassay laboratory, we handled around 110,000 blood samples for prostate specific antigen (PSA) tests for screening or disease diagnosis every year. It proved that PSA is still a clinically favorite and preferential item as a serum marker for prostate diseases, especially for urologist. Patients aged over 50 years who visit our urological out-patient-department are routinely requested for PSA test. From literature reviews, we found that PSA used to be a powerful prostate tumor marker. Up to now, the specificity of PSA for detecting prostate disorders is good, but not for prostate cancer because increased PSA levels are often seen in prostate related diseases such as benign prostate hypertrophy and prostatitis or even prostate-unrelated diseases such as breast cancer. These drawbacks inevitably decrease the clinical value of PSA in prostate cancer detection. Methods provided in this presentation may enable us to use PSA test properly and efficiently in the detection of prostate cancer, avoiding mis-interpretation from other diseases. While popularity and controversy of PSA remain, related works are needed to recognize the dimensions of PSA and reevaluate its use in clinical applications. |
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