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題名 | 人類非小細肺癌細胞轉殖p21□促進玫瑰樹鹼的凋亡效應=Ellipticine-induced Apoptosis in Human Non-small Cell Lung Cancer Cells with Ectopic Expression of p21□ |
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作者 | 林佳薇; 林銘儀; 路淑怡; 黃慧滇; 方剛; | 書刊名 | BioFormosa |
卷期 | 42:2 2007.12[民96.12] |
頁次 | 頁99-104 |
分類號 | 415.138 |
關鍵詞 | 人類非小細肺癌細胞; 玫瑰樹鹼; 凋亡; Human non-small cell lung cancer cells; Ellipticine; Apoptosis; |
語文 | 中文(Chinese) |
中文摘要 | 轉殖p53所調控的下游基因p21□(p21)至p53突變非小細肺癌細胞株H1437,將穩定成長之細胞以topoisomerase Ⅱ抑制劑ellipticine處理後,其敏感率會增加,這個改變,是因為所細胞凋亡增加所致。因此未來可以發展藉外源性p21基因,增加對p53突變的癌細胞的藥物敏感性。 |
英文摘要 | Topoisomerase II inhibitor ellipticine-induced apoptosis in human non-small cell lung cancer cells H1437 with ectopic expression of p21□ (p21), that is distinct from the parental cells that are drug resistant. The enhanced cytotoxic effect can be achieved through apoptosis. The results indicated that the sensitivity of ellipticine in p53-mutated NSCLC cells can be enhanced through introduction and nuclear migration of downstream of p53 regulator, p21. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。