頁籤選單縮合
題 名 | 中草藥成分在抗癌及抗血管新生的作用研究與活性成分來源之基原鑑定總報告=Studies of Chinese Herbal Medicines on Anticancer and Antiangiogenic Effects and Analysis of Genetic Variance of Active Ingredients |
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作 者 | 顧記華; | 書刊名 | 中醫藥年報 |
卷 期 | 25:4 2007.10[民96.10] |
頁 次 | 頁177-207 |
專 輯 | 中醫藥品質管理相關研究 |
分類號 | 414.51 |
關鍵詞 | 抗癌作用; 雙萜類化合物; 凋亡作用; Anti-tumor activity; Diterpenoid; Apoptosis; |
語 文 | 中文(Chinese) |
中文摘要 | 在過去的三年內,本計畫已完成超過250種中草藥、臺灣特有植物、天然物等成分物質對於人類腫瘤細胞的抗癌活性分析(原預計3年執行200種)。研究結果發現數種成分具有不錯的抗癌活性,其中以91年度的臺灣嘉賜木成分CMB、92年度的臺灣嘉賜木的clerodane雙萜類化合物中的12種成分JCM1-12、93年度的兔兒菜成分、Bromovulone III及YCS-IQ的作用最好,其作用於人類肝癌細胞HA22T及Hep3B細胞、肺癌細胞A549、前列腺癌細胞PC-3都有不錯的抗癌活性。以電子顯微鏡觀察、染色體濃聚分析、多項生化實驗分析結果得知,這些活性成分都能經由一些作用機制導致腫瘤細胞的凋亡作用(Apoptosis)。這些研究成果大多於近幾年內陸續發表。此外,這些成分的來源物質之基原鑑定部分也順利完成。 |
英文摘要 | We have done a screening test on the examination of anticancer effect in various components from natural products, Chinese herbal medicines and plants in Taiwan in the past three years. In this project, we have screened more than 250 compounds and found several active components, such as the CMB compound from Casearia membranasea (the 1st year project), the clerodane diterpenoids JCM1 to JCM12 from Casearia membranasea (the 2nd year project) and the 兔兒菜 compound, bromovulone III and YCS-IQ (the 3rd year project). The anti-tumor activities of these components have been examined in several human cancer cell lines, including hepatocellular carcinoma HA22T and Hep3B cells, non-small lung cancer cell A549 and hormone-resistant prostate cancer PC-3. The anti-tumor mechanisms of these compounds have been identified using several biochemical analysis methods. Most of the studies have been published in these years. Additionally, the genetic identification of the parent sources of these compounds has also been finished. |
本系統中英文摘要資訊取自各篇刊載內容。