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來源資料
頁籤選單縮合
題 名 | 中西藥交互作用體外預測模式之建構與評量=Construction and Evaluation of in Vitro Model for Prediction of Herb-Drug Interactions |
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作 者 | 許明照; | 書刊名 | 中醫藥年報 |
卷 期 | 25:1 2007.10[民96.10] |
頁 次 | 頁207-237 |
專 輯 | 中醫藥療效評估之研究 |
分類號 | 413 |
關鍵詞 | 中西藥交互作用; 酵素抑制作用; 肝臟代謝酵素; Herbal medicines; Cytochrome 3A4; Enzymes inhibition; |
語 文 | 中文(Chinese) |
中文摘要 | 為了研究中草藥與西藥可能發生的藥物交互作用,我們選擇了數種繖形科之中草藥及其相關並常被使用之複方方劑以兩種萃取方式:熱水萃取與40%乙醇浸漬來測試體外試驗中繖形科之中草藥及其相關複方方劑之抽出物對於人體代謝藥物的主要酵素cytochrome P450 3A4 (CYP3A4)之抑制作用。我們以模式藥物nifedipine被酵素代謝後之代謝物的量來測定白芷、羌活、當歸、防風、獨活之水萃取液及乙醇水溶液浸漬液對於肝臟酵素抑制作用的程度。從實驗中的結果,可以確定每一個樣品其抑制強弱主要是由其疏水性部分所含的物質決定。在所有檢品中,又以羌活的乙醇水溶液浸漬液推測因含有多量furanocoumarins類化合物而具有最顯著的酵素cytochrome P450 3A4 (CYP3A4)之抑制作用。此外,有些處方製劑的疏水性分離液較親水性分離液有較強之酵素抑制作用,因此可以推斷出中草藥處方製劑所含之furanocoumarins類化合物造成酵素之抑制作用。所以,這些結果顯示出對於進一步研究中草藥與西藥是否發生藥物交互作用是非常必須的。 |
英文摘要 | To investigate the possible drug interaction with Chinese herbal medicine, hot water deconctions or 40% ethanol infusions of several Umbelliferous and their prescriptions were examined in vitro for their abilities to inhibit rat cytochrome P450 3A4 (CYP3A4). Addition of each decoction or infusion from Bai Zhi (Angelica dahurica radrix), Qiang Huo (Notopterygium incisum root), Danggui (Chinese Agelica radrix), Fang Feng (Saposhnikovia divaricata radrix), Duhuo (Angelica japonica) Resulted in various degrees of human CYP3A4 inhibition as determined by microsomal oxidized nifedipine. The inhibitory potency was consistent with the abundance of the hydrophobic components for each sample. Experiments on the infusion of a Qiang Huo showed the major role of furanocoumarins on rat CYP3A4 inhibition. Some formulated prescriptions, however, showed intense inhibition with their hydrophobic fractions rather than with their hydrophilic fractions, suggesting that components furanocoumarins in herbal prescriptions may cause CYP3A4 inhibition. These results indicated the necessity of intensive investigations on the possible drug interaction with herbal medicines. |
本系統中英文摘要資訊取自各篇刊載內容。