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題名 | 自體免疫性血小板低下紫斑症與幽門螺旋桿菌感染的關係=Immune Thrombocytopenic Purpura and Helicobacter Pylori Infection |
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作者 | 林正耀; 黃文聰; 曹朝榮; 李致慧; Lin, Cheng-yao; Huang, Wen-tsung; Taso, Chao-jung; Lee, Chih-hui; |
期刊 | 內科學誌 |
出版日期 | 20070800 |
卷期 | 18:4 2007.08[民96.08] |
頁次 | 頁182-188 |
分類號 | 415.623 |
語文 | chi |
關鍵詞 | 自體免疫性血小板低下紫斑症; 幽門螺旋桿菌; 根除療法; 交叉擬態; 血小板凝集; Immune thrombocytopenic purpura; Helicobacter pylori; Eradication therapy; Cross mimicry; Platelet aggregation; |
中文摘要 | 自體免疫性血小板低下紫斑症是血小板受到自體免疫抗體結合,引發自體免疫破壞,導致血小板低下的疾病。但是對於自體抗體如何產生的原因及機轉目前仍未有定論。而幽門螺旋桿菌的發現對於胃潰瘍、胃腺癌與胃淋巴癌以及一些自體免疫性疾病的成因與治療帶來新的曙光。近來許多報告指出,在自體免疫性血小板低下紫斑症合併有幽門螺旋桿菌感染的患者中,成功的幽門螺旋桿菌根除治療後,約有一半的病人血小板數目會增加。藉由分子擬態、血小板凝集的理論以及血清遺傳學的分析研究,可解釋其中可能的關聯與機轉。如此,一方面可以讓我們了解自體免疫性血小板低下紫斑症產生自體免疫抗體可能的成因,一方面也替未來的治療提供新的方向。 |
英文摘要 | Immune thrombocytopenic purpura (ITP) is a disorder characterized by a low platelet count. The peripheral blood platelets are conjugated with anti-platelet antibodies and then are destroyed by autoimmune system. However, the definite causes and mechanisms of how to induce those auto-antibodies are not clear. The infection of Helicobacter Pylori (H. Pylori) has been documented to be associated with peptic ulcers, gastric cancer and gastric lymphoma as well as some auto-immune diseases. And the marvelous finding has approached a new therapeutic milestone for those diseases. Recently, numerous studies have reported that: about half of ITP patients simultaneously infected with will H. Pylori improve their platelet counts after successful eradication of their H. Pylori infections. Theories of molecular cross mimicry, platelet aggregation and serological studies have tried to explain the relations and possible mechanism. Therefore, we might understand the causes and mechanisms of the evolution of auto-antibodies in ITP, and then conduct a new strategy to treat those ITP patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。