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題 名 | 表皮生長因子對遲滯期的腎近端小管細胞內細胞骨骼的影響 |
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作 者 | 溫小娟; 湯銘哲; | 書刊名 | 元培學報 |
卷 期 | 4 1997.12[民86.12] |
頁 次 | 頁51-72 |
分類號 | 415.74 |
關鍵詞 | 表皮生長因子; 細胞骨骼; 肌動蛋白; 貝它--微小管絲; 細胞角蛋白絲; Epidermal growth factor; Cytoskeleton; Actin; Cytokeratin; β-tubulin; |
語 文 | 中文(Chinese) |
中文摘要 | 表皮生長因子(Epidermal Growth Factor;EGF),為一個53個胺基酸的多胜�鬊� 。它對腎近端小管細胞為相當強的生長促進劑。但在以往的文獻報導,尚未成功地指出以 細胞個數或細胞蛋白質量測出EGF可以加速腎近端小管細胞的增殖。因此,我們擬利用免子 腎近端小管細胞的初級培養來探討 EGF 是否能增加遲滯期 (lag phase) 細胞增殖的數量。 本篇係於一連串 EGF 與細胞生長關係探討過程中:我們先觀察細胞形態的變化。 由細胞形 態的觀察中發現 EGF 作用二 ~ 三小時之後細胞形態便開始發生改變。因此,我們接著便去 探討 EGF 如何改變細胞內骨骼的形狀。 利用免疫細胞化學染色法來探討肌動蛋白 (actin) ,貝它一微小管絲 (β -tubulin) 及細胞角蛋白絲 (cytokeratin) 的變化。我們發現只要 濃度大於 0.1ng/ml 就會造成 actin 的重新分佈,cytokeratin 重新組合及 microtubules 聚集成束。在我們發現中最有趣的是:EGF 可造成細胞骨骼改變的最小濃度剛好是在生理的血液 濃度範圍之內,故我們推測 EGF 可能在細胞形態維持上扮演某些角色。 |
英文摘要 | Epidermal growth factor (EGF), a 53-amino acid polypeptide, is a potent mitogen for proximal tubular cells. However, no one has successfully demonstrated that EGF accelerated proliferation of proximal tubular cells. Using primary culture of rabbit proximal tubules, we try to find whether EGF promoted proliferation of proxitubular cells in lag phase or not. First, we observed the morphorlogical changes of proximal tubular cells in lag phase after 2-3 hr incubation of 10 ng/ml EGF. Using immunocytochemical methods to determine whether EGF altered the distribution pattern of actin, cytokeratin and β -tubulin, we found that EGF, induced redistribution of actin, reorganization of cytokeratin filaments and bundling of microtubules at the dose of 0.1 ng/ml and up. Interestingly, the minimal dosage of EGF to induce cytoskeletal changes of proximal tubules lies within the physiological range of plasma concentration, sugesting that EGF play some roles in maintenance of cell morphology. |
本系統中英文摘要資訊取自各篇刊載內容。