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| 題 名 | 鼻咽癌病患於放射治療後生活品質之複迴歸分析=Multiple Regression Analysis of the Quality of Life for Patients with Nasopharyngeal Carcinoma after Radiotherapy |
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| 作 者 | 許維中; 陳斯榮; 詹淑卿; 陳宇嘉; 丁禮莉; 鍾娜娜; 王博民; 劉博仁; 林高德; | 書刊名 | 中華放射線醫學雜誌 |
| 卷 期 | 31:6 民95.12 |
| 頁 次 | 頁289-296 |
| 分類號 | 416.879 |
| 關鍵詞 | 鼻咽癌; 生活品質; 放射治療; EORTC; Enropean organization for research and treatment of cancer; Nasopharyngeal carcinoma; Quality of life; Radiotherapy; |
| 語 文 | 中文(Chinese) |
| 中文摘要 | 本研究之目的是評估時間因素、疾病嚴重度及個人屬性變項對鼻咽癌病患放射治療後的生活品質指標之影響。 總共有兩機構三百三十二位鼻咽癌病患使用傳統放射治療,且符合鼻咽部放射劑量不低於70 Gy 、頸部淋巴區放射劑量不低於50 Gy 者被邀請參與研究。鼻咽部及頸部的平均放射治療劑量各為70.69 ±2.49 Gy 及60.25 ±6.88 Gy 。病患追蹤時間均在放射治療結束後三個月以上 (介於3 至360 個月,平均追蹤時間為52.85 ±61.78 個月),單次性填寫EORTC QLQ C-30 及EORTC QLQ-H&N35 的生活品質量表,以此作為評估之依據。 將時間因素 (治療後三至六個月、治療後六至十二個月、治療後一至五年及治療後五年以上)、疾病嚴重度 (早、晚期)及個人屬性變項,利用複迴歸分析後,可發現以「時間因素」為影響生活品質的最主要因子,其次為「家庭收入」,而疾病嚴重度與其餘個人屬性變項則對不同生活品質指標有不同程度的影響。若以整體生活品質改善程度而言,影響因子為「時間因素」 (為倒U 型之曲線關係)以及「家庭收入」兩項。 整體來說,以「時間因素」與「家庭收入」為影響生活品質的主要因子。針對「時間因素」進一步探討,結果顯示多數生活品質指標於治療6 個月後較有明顯改善,到長期時則漸趨穩定。而較高的家庭收入,其生活品質也較佳。本研究提供臨床醫師在評估治療風險、治療後復健、心理諮商及衛教照護時有所依據,對於了解鼻咽癌病患治療後之生活品質亦有所幫助。 |
| 英文摘要 | The purpose of this study is to evaluate the effects of time interval, the severity of the disease and personal characteristic variables upon quality of life (QoL) for patients with nasopharyngeal carcinoma after radiotherapy. Three hundred and thirty-two with nasopharyngeal carcinoma patients treated by conventional radiotherapy technique in two institutions were invited to participate; all received not less than 70 Gy to nasopharynx and not less than 50 Gy to neck. The mean irradiation dosage to nasopharynx and neck were 70.69 ± 2.49 Gy and 60.25 ± 6.88 Gy, respectively. Health-related quality of life was assessed 3 months or later after completion of radiotherapy (the mean follow up period ranged from 3 to 360 months, the mean follow up period: 52.85 ± 61.78 months) by means of the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ C-30) and the EORTC head and neck cancer-specific questionnaire (QLQ H&N-35) . After completion of radiotherapy, the periods for patients to fill in the questionnaire were divided into 4 groups: 3-6 months, 6-12 months, 1-5 years and more than 5 years. In addition, the severity of the diseases was divided into early and late stages. By multiple regression analysis, the “time interval” was the most important factor of the QoL. The next was “family income”. Besides, the severity of disease and the other personal characteristic variables affected the different degrees for the different items of the QoL. The factors of affecting global QoL were the time interval (invert U curve) and family income. As a whole, time interval and family income were the most important factors to affect the QoL. In respect of time interval, most items of QoL were improved 6 months after completion of radiotherapy and stablized in the long term. Higher family income showed the better QoL. Our study provided clinical physicians the assessement of the risk for treatment, rehabilitation after treatment, mental consultation and supportive care. It was also helpful for us to understand the QoL for patients with nasopharyngeal carcinoma after radiotherapy. |
本系統中英文摘要資訊取自各篇刊載內容。