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題名 | Rifabutin-induced Hypopyon Uveitis in Patients with Acquired Immunodeficiency Syndrome Infected with Mycobacterium Avium Complex=Rifabutin相關之葡萄膜炎--發生在治療後天免疫不全症候群合併非典型結核病感染之病人 |
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作者姓名(中文) | 王馨慧; 張由美; 林穎正; 胡信傳; 王永衛; | 書刊名 | 中華醫學會雜誌 |
卷期 | 70:3 2007.03[民96.03] |
頁次 | 頁136-139+CA25 |
分類號 | 418.2219 |
關鍵詞 | 人類免疫不全病毒; 前房蓄膿; 禽型分枝桿菌複合體; 葡萄膜炎; HIV; Hypopyon; Mycobacterium avium complex; Rifabutin; Uveitis; |
語文 | 英文(English) |
英文摘要 | Rifabutin is a semi-synthetic antimycobacterial agent mainly used in the prophylaxis and treatment of Mycobacterium avium complex (MAC) in acquired immunodeficiency syndrome patients. Uveitis as a side effect of rifabutin has been recognized and established since 1994, but there was no case previously described in Taiwan so far. We report 2 cases of rifabutin-induced hypopyon uveitis in patients with human immunodeficiency virus and MAC infection. Both patients received the regimen of clarithromycin and rifabutin to treat MAC infection. Uveitis resolved after discontinuing of rifabutin and treatment with topical corticosteroid and mydriatics. Early recognition of this entity can prevent invasive ocular procedures and treatments. Doctors who prescribe rifabutin should be aware of this ocular complication of uveitis and drug–drug interactions. Ophthalmologists should put this on the list of differential diagnoses for uveitis. |
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