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題名 | 低劑量L-Name與耐力性運動訓練對大鼠肝醣儲存的影響=Effect of Low-Dosage Treatment of L-NAME and Endurance Training on Glycogen Storage in Rats |
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作者姓名(中文) | 蘇易廷; 林嘉志; 謝伸裕; | 書刊名 | 成大體育 |
卷期 | 39:3=50 民95.07 |
頁次 | 頁26-35 |
分類號 | 528.9013 |
關鍵詞 | 一氧化氮; 耐力性運動訓練; 肝醣; 骨骼肌; NO; Endurance training; Glycogen; Skeletal muscle; L-NAME; |
語文 | 中文(Chinese) |
中文摘要 | 目的:觀察低劑量一氧化氣合成時非選擇性抑制劑L-NAME 與耐力性運動訓練對大鼠骨骼肌肝醣與肝臟肝醣的影響。方法:23隻Wistar品系六週齡公鼠隨機分為四組:Control組(n=6),L-NAME組(n=6),Exercise組(n=6)及L-NAME + Exercise組(n=5)。大鼠的耐力訓練方式以原地跑步機進行五週:由第一週15 公尺/分鐘(18分鐘)逐漸增強至第五週為24公尺/分鐘(60 分鐘)。L-NAME(5 毫克/公斤/日,5 天/週)的餵食則在運動訓練前一小時完成。測量項目包括平均動脈壓、比目魚肌檸檬酸合成酶活性、腓腸紅肌與比自魚肌及肝臟之肝醣。統計方法以獨立樣本雙因子變異數分析檢定,顯著水準至少須達p≦.05 。測量數據以平均數±標準誤表示。結果:耐力運動訓練及低劑量L-NAME 對大鼠平均動脈壓及腓腸肌白肌肝醣含量緣無顯著影響(p>.05),但耐力運動訓練能顯著增加檸檬酸合成酶活性、腓腸紅肌與比目魚肌肝醣及肝臟肝醣含量(p<.001), 而低劑量L-NAME 亦能顯著增加霏腸肌紅肌肝醣含量(p<.05),並顯著降低肝臟肝醣含量(p<.05)。結論:耐力運動訓練能增加骨骼肌紅肌肝醣含量及檸檬酸合成酶活性,低劑量L-NAME 則對骨骼肌紅肌肝醣含量有加成的影響,並降低肝臟肝醣含量,顯示低劑量L-NAME能影響肝醣儲存的位置。 |
英文摘要 | PURPOSE: To investigate the effects of low-dosage L-NAME and endurance training on skeletal muscle and liver glycogen storage in rats. METHODS: Twenty-three male Wistar rats (6-week old) were randomly divided into four groups: Control (n = 6), L-NAME (n = 6), Exercise (n = 6) and L-NAME + Exercise (n = 5). Rats were training on treadmill at a belt speed 15 m/min for 18 min during the 1st week, and increased to 24 m/min for 60 min during the 5th week. L-NAME(5 mg/kg/day, 5 days/wk) was fed one hour before the training. After 5 wks, rats were analyzed for mean blood pressure, citrate synthase activity(CS), and the glycogen contents of soleus, gastrocnemius and liver. Independent 2×2 ANOVA was used to evaluate the mean difference. The significance was set at p ~ .05. Data were expressed at MEAN ± SEM. RESULTS: The analysis indicated mean blood pressure and the glycogen content of gastrocnemius white muscle was not significantly affected in endurance trained rats and L-NAME treated rats(p> .05), but CS activity and glycogen content of gastrocnemius red muscle, soleus muscle and liver was significant enhanced in endurance trained rats (p < .001). Also, gastrocnemius red muscle glycogen in L-NAME treated rats were significantly increased(p <.05), Analysis also shows L-NAME treatment significantly decreased liver glycogen (p < .05). CONCLUSION: Endurance training could increase skeletal red muscle glycogen content and CS activity of rat. Low-dose L-NAME treatment could increase skeletal red muscle but decrease liver glycogen content in endurance trained rat. It is evident that low-dose L-NAME treatment could affect the location of storage. |
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