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題 名 | A Study of VEGF and VEGF-d in the Patients of Liver Cancer=肝癌病人血清中VEGF與VEGF-d之研究 |
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作 者 | 柯成國; 陳鴻曜; 阮仲洲; 曾建森; 羅海韻; 施登富; 羅偉菁; | 書刊名 | Medical Journal of South Taiwan |
卷 期 | 1:1 民95.06 |
頁 次 | 頁40-46 |
分類號 | 415.536 |
關鍵詞 | 血管內皮細胞生長因子; 肝細胞癌; 血管內皮細胞生長因子-d型; Vascular endothelial growth factor; Hepatocellular carcinoma; Vascular endothelial growth factor-d; |
語 文 | 英文(English) |
中文摘要 | 目的:血管內皮細胞生長因子(Vascular Endothelial Growth Factor, VEGF)及血管內皮細胞生長因子-d型(VEGF-d),已被研究出與血管及淋巴管的生成有關。因此,我們將探討手術切除後,各項臨床結果與血清中VEGF及VEGF-d表現量之關係。方法:本研究實驗對象共32個病人(22位男性;10位女性)。皆以病理檢查證實為肝癌病人。利用免疫分析套組(ELISA)分析32位病人在接受手術後,血清中的VEGF及VEGF-d表現量,再將表現結果各自與腫瘤大小、腫瘤分化程度、腫瘤類型、及轉移狀況做比較。結果:由圖1可知VEGF及VEGF-d表現量與腫瘤大小的關係。血清VEGF-d表現量在腫瘤小於3公分的族群中,表現較高,表現量為615.2± 161.5 ng/dl。在手術後,沒有復發、轉移、腹內轉移、及肺部轉移四種狀況中,其VEGF-d表現量各為412.9 ± 46.5、613.3 ± 149.0、583.5 ± 171.8、701.9 ± 235.6ng/dl。由以上可知,腫瘤長距離的轉移狀況,伴隨血清中有VEGF-d高度表現情況發生。結論:在肝外轉移、肝腫瘤的分化程度、及肝腫瘤類型的族群中,可發現血清中有VEGF及VEGF-d高度表現。因此,可特別注意血清中有高度VEGF-d表現的病人,避免早期復發或轉移。 |
英文摘要 | Purpose: The presence of Vascular Endo-thelial Growth Factor (VEGF) and VEGF-d had relationship with the capillary for-mation of vessels and lymph vessels. There-fore, we try to conduct this study to verify the result of serum levels of VEGF and VEGF-d and clinical results after operative resection.Methods: Thirty-two patients (22 in male & 10 in female) were encountered in this study. In those patients were proved to be hepato-cellular carcinoma (HCC) with pathologic study after tumor resection. The serum level of VEGF and VEGF-d were measured with ELISA methods. The valuables were an-alyzed according to the tumor size, diff-erentiation, type of tumor and metastasis as well.Results: The values of VEGF and VEGF-d according to the size of tumor were shown in the figure 1, The serum VEGF-d level was found 615.2± 161.5 ng/dl higher in the group of small tumor less than 3cm. The serum values of VEGF-d in the group of no recurrence, metastasis, intra-abdominal metastasis, and lung metastasis were found 412.9± 46.5, 613.3± 149.0, 583.5± 171.8, 701.9± 235.6 ng/dl respectively. Long distance metastasis has the higher serum level of VEGF-d.Conclusion: The high level of VEGF and VEGF-d was found in the group of extra-hepatic metastasis, moderate differentiation and diffuse type of HCC. Therefore, in case of high level of VEGF-d was noted, it is necessary to care the possibility of early recurrence or metastasis. |
本系統中英文摘要資訊取自各篇刊載內容。