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題 名 | Clinical Analysis of Psoriatic Inpatients--A 10-year Retrospective Study=乾癬住院病人之臨床分析--10年之回顧研究 |
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作 者 | 葉明雄; 蔡呈芳; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 25:2 2007.06[民96.06] |
頁 次 | 頁103-111 |
分類號 | 415.731 |
關鍵詞 | 乾癬; Psoriasis; Inpatients; Exacerbation; |
語 文 | 英文(English) |
中文摘要 | 乾癬為常見之慢性發炎性皮膚疾病,通常在門診治療。近年來全球皆有減少乾癬病人住院之趨勢。為了分析造成乾癬病患住院的原因,尤其是引起乾癬惡化之因素,我們針對於民國85年4月至民國95年4月間在台大醫院住院乾癬患者進行一回顧性研究。總共收集120個病患資料。平均每天僅一位乾癬患者住院。男女比為2.9:1。入院時平均年齡為45.1歲。平均住院天數為15.3天。未發現主要之住院季節。慢性板塊型乾癬為乾癬住院病患最常見之臨床表現。住院天數與較高年齡及乾癬臨床表現有顯著相關。住院原因包括急性惡化(73.3%)、門診治療失敗(15%)、初步診斷未明(10%)、及乾癬治療所造成之非乾癬性副作用(1.7%)。急性惡化原因最多屬於未知(35.2%),其次依序是感染(29.5%)、乾癬治療(9.1%)、停用全身性類固醇(5.7%)、中藥(4.5%)、健康食品(4.5%)、外用物質(4.5%)、酗酒(3.4%)、其他併存疾病的治療藥物(2.3%)、及氣候(l.1%)。目前已知有許多原因會造成乾癬惡化。在此研究中也發現一些之前未被報告過之惡化因素。因為這是回顧性研究,所以仍有相當比例病人未能找出明顯惡化因素。以此篇研究為基礎,進一步實施系統性前瞻研究將有助於了解乾癬成因及致病機轉。 |
英文摘要 | Psoriasis is a common chronic inflammatory skin disease that is usually managed in outpatient clinic. There is a trend to reduce hospitalization for psoriasis globally in recent years. To analyze the reasons necessitating hospitalization for psoriasis, especially the causes of acute exacerbation, a retrospective study was carried out in psoriatic inpatients admitted to National Taiwan University Hospital between April 1996 and April 2006. Available data were obtained from 120 patients. On average, there was only one psoriasis admission each month. The male to female ratio was 2.9:1. The mean age on admission was 45.1 years. The mean duration of hospitalization was 15.3 days. No predominant season of admission was found. Chronic plaque psoriasis was the most common clinical type in psoriatic inpatients. The duration of hospitalization was significantly associated with older age and the clinical type of psoriasis. The reasons of admission were acute exacerbation (73.3%), outpatient treatment failure (15%), uncertain initial diagnosis (10%), and nonpsoriasis-related side effects of psoriatic treatment (1.7%). The most causes of acute exacerbation were unknown (35.2%), followed by infection (29.5%), psoriatic treatment (9.1%), withdrawal of systemic steroid (5.7%), Chinese medicine (4.5%), healthy food (4.5%), topical agents (4.5%), alcohol (3.4%), medication for other concomitant diseases (2.3%), and climate (1.1%). Numerous factors are known to exacerbate psoriasis. In this study, there are some exacerbating factors of psoriasis that have not been reported before. Because this is a retrospective study, there are still a considerable percentage of patients in whom no obvious exacerbating factor is identified. Further systematic prospective researches on the basis of this study will be helpful to understand the causes and pathogenesis of psoriasis. |
本系統中英文摘要資訊取自各篇刊載內容。